Phosphorylation of Plexin-A

Stable Identifier
R-MMU-421143
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Phosphorylation of Plexin-A

Sema3A binding to Neuropilin-1:Plexin-A complex results in conformational change of plexin-A and this conformational change permits Fes nonreceptor tyrosine kinase to bind and phosphorylate Plexin-A. The specific tyrosine residues phosphorylated in the cytoplasmic domain of plexins in response to semaphorin stimulation have not yet been identified.

Literature References
PubMed ID Title Journal Year
12093729 Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling

Mitsui, N, Goshima, Y, Takahashi, S, Yamamura, H, Inatome, R, Yanagi, S

EMBO J 2002
17607942 The CRMP family of proteins and their role in Sema3A signaling

Strittmatter, SM, Schmidt, EF

Adv Exp Med Biol 2007
Participants
Catalyst Activity

protein tyrosine kinase activity of Fes [cytosol]

Orthologous Events
Authored
Reviewed
Created
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