Reactome | Fes [cytosol]

Fes [cytosol]

Stable Identifier

R-MMU-421078

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Proto-oncogene tyrosine-protein kinase Fes/Fps, FES_MOUSE

Locations in the PathwayBrowser

Expand all

Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - Semaphorin interactions (Mus musculus)
      - CRMPs in Sema3A signaling (Mus musculus)
        
        Tyrosine phosphorylation of CRMPs by Fes (Mus musculus)
        
        Fes [cytosol] (Mus musculus)
        
        Sema3A:NP-1:Plexin-A:Fes:CRMP [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Mus musculus)
        
        Fes [cytosol] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Mus musculus)
        
        Fes [cytosol] (Mus musculus)
      - Sema3A PAK dependent Axon repulsion (Mus musculus)
        
        Activation of PAK by Rac1 (Mus musculus)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Mus musculus)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Mus musculus)
        
        Fes [cytosol] (Mus musculus)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Mus musculus)
        
        Fes [cytosol] (Mus musculus)
        
        Autophosphorylation of PAK (Mus musculus)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Mus musculus)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Mus musculus)
        
        Fes [cytosol] (Mus musculus)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Mus musculus)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Mus musculus)
        
        Fes [cytosol] (Mus musculus)
        
        Phosphorylation of LIMK-1 by PAK (Mus musculus)
        
        Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Mus musculus)
        
        Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Mus musculus)
        
        Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Mus musculus)
        
        Fes [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P16879 Fes

Gene Names

Fes, Fps

Chain

chain:1-822

Reference Genes

BioGPS Gene:14159 Fes

ENSEMBL:ENSMUSG00000053158.11 Fes

KEGG Gene (Mus musculus):14159 Fes

Monarch:14159 Fes

NCBI Gene:14159 Fes

UCSC:P16879 Fes

Reference Transcript

Other Identifiers

10564938

14159

1427368_x_at

1452410_a_at

17492575

4306768

4356298

4541416

4591111

4662372

4672629

4758608

4779682

4783122

4797380

4936068

4936666

4957013

4963997

4995197

5032159

5085432

5110831

5159569

5214832

5227175

5234157

5244786

5297341

5496011

5588819

92188_s_at

GE38522

GO:0000166

GO:0001578

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005737

GO:0005794

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0006468

GO:0006935

GO:0007010

GO:0007098

GO:0007155

GO:0008017

GO:0008092

GO:0008289

GO:0008360

GO:0009898

GO:0010976

GO:0015630

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0030154

GO:0030155

GO:0031116

GO:0031410

GO:0034987

GO:0035091

GO:0036211

GO:0042127

GO:0043226

GO:0043304

GO:0045595

GO:0045639

GO:0045657

GO:0048856

GO:0048870

GO:0051450

GO:0060038

GO:0065003

GO:0070161

GO:0071305

GO:0140096

GO:2000145

ILMN_2695793

ILMN_2771794

X12616_s_at

mMC012249

Participates

as a member of

Tyrosine kinases [cytosol] (Mus musculus)

as a component of

as an input of

Phosphorylation of Plexin-A (Mus musculus)

Inferred From

FES [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_006540667.1, NP_034324.2

Ensembl

ENSMUSP00000079733, ENSMUSG00000053158, ENSMUST00000080932

PRO

P16879

MGI

95514

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01901 H2-K1	20	H2-K1 [early endosome membrane] (R-MMU-1236895-9) H2-K1 [early endosome membrane] (R-MMU-1236799-9) H2-K1 [early endosome membrane] (R-MMU-1236872-9) H-2 class I histocompatibility antigen, K-B alpha chain [phagocytic vesicle membrane] (R-MMU-1236736) H2-K1 [phagocytic vesicle membrane] (R-MMU-1236760-9) H2-K1 [phagocytic vesicle membrane] (R-MMU-1236887-9) H2-K1 [phagocytic vesicle membrane] (R-MMU-1236753-9) H2-K1 [recycling endosome membrane] (R-MMU-8863915-9) H2-K1 [recycling endosome membrane] (R-MMU-8863942-9) H2-K1 [recycling endosome membrane] (R-MMU-8863878-9) H2-K1 [plasma membrane] (R-MMU-197572-9) H2-K1 [Golgi membrane] (R-MMU-983394-9) H2-K1 [Golgi membrane] (R-MMU-983387-9) H2-K1 [Golgi membrane] (R-MMU-983379-9) H2-K1 [ER to Golgi transport vesicle membrane] (R-MMU-983354-9) H2-K1 [ER to Golgi transport vesicle membrane] (R-MMU-983362-9) H2-K1 [ER to Golgi transport vesicle membrane] (R-MMU-983375-9) H2-K1 [azurophil granule membrane] (R-MMU-6799339-9) H2-K1 [secretory granule membrane] (R-MMU-6804794-9) H2-K1 [secretory granule membrane] (R-MMU-6803292-9)	0.463	3