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Btk [cytosol]
Stable Identifier
R-MMU-2685636
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Tyrosine-protein kinase BTK ecNumber2.7.10.2/ecNumber, BTK_MOUSE, Btk
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Mus musculus)
BTK binds BTK inhibitors (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Mus musculus)
BTK:PIP3 [plasma membrane] (Mus musculus)
Btk [cytosol] (Mus musculus)
BTK:BTK inhibitors [plasma membrane] (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Mus musculus)
BTK:PIP3 [plasma membrane] (Mus musculus)
Btk [cytosol] (Mus musculus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Mus musculus)
BTK:PIP3 [plasma membrane] (Mus musculus)
Btk [cytosol] (Mus musculus)
Btk [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
DAP12 interactions (Mus musculus)
DAP12 signaling (Mus musculus)
Activation of RAC1 by VAV2/3 (Mus musculus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Mus musculus)
Btk [cytosol] (Mus musculus)
Phosphorylation and activation of VAV2/VAV3 by SYK (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
Btk [cytosol] (Mus musculus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Mus musculus)
Btk [cytosol] (Mus musculus)
Phosphorylation of BTK by p-SYK (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
Btk [cytosol] (Mus musculus)
Recruitment of VAV and BTK to p-SLP-76 (Mus musculus)
Btk [cytosol] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
Btk [cytosol] (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated Ca+2 mobilization (Mus musculus)
Phosphorylation of TEC kinases by p-SYK (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Mus musculus)
TEC,BTK,ITK,(TXK) [cytosol] (Mus musculus)
Btk [cytosol] (Mus musculus)
Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
Regulation of actin dynamics for phagocytic cup formation (Mus musculus)
Src phosphorylate WASP,N-WASP (Mus musculus)
Src-kinases [cytosol] (Mus musculus)
Btk [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (12/13) signalling events (Mus musculus)
BTK in G alpha (12)-BTK complex is activated (Mus musculus)
G alpha (12):BTK [plasma membrane] (Mus musculus)
Btk [cytosol] (Mus musculus)
G alpha (12) binds BTK (Mus musculus)
Btk [cytosol] (Mus musculus)
G alpha (12):BTK [plasma membrane] (Mus musculus)
Btk [cytosol] (Mus musculus)
G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Mus musculus)
Btk [cytosol] (Mus musculus)
G alpha (12):BTK [plasma membrane] (Mus musculus)
Btk [cytosol] (Mus musculus)
G alpha (q) signalling events (Mus musculus)
Active Gq binds BTK (Mus musculus)
Active Gq:BTK [plasma membrane] (Mus musculus)
Btk [cytosol] (Mus musculus)
Btk [cytosol] (Mus musculus)
BTK in active Gq-BTK complex is activated (Mus musculus)
Active Gq:BTK [plasma membrane] (Mus musculus)
Btk [cytosol] (Mus musculus)
Gq-BTK complex dissociates to Active BTK and Gq (Mus musculus)
Active Gq:BTK [plasma membrane] (Mus musculus)
Btk [cytosol] (Mus musculus)
Btk [cytosol] (Mus musculus)
G-protein beta:gamma signalling (Mus musculus)
G beta:gamma signalling through BTK (Mus musculus)
BTK in PIP3:BTK:G beta-gamma complex is activated (Mus musculus)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Mus musculus)
Btk [cytosol] (Mus musculus)
G beta-gamma complex and PIP3 recruit BTK to membrane (Mus musculus)
Btk [cytosol] (Mus musculus)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Mus musculus)
Btk [cytosol] (Mus musculus)
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Mus musculus)
Btk [cytosol] (Mus musculus)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Mus musculus)
Btk [cytosol] (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases Activate WASPs and WAVEs (Mus musculus)
Src phosphorylate WASP,N-WASP (Mus musculus)
Src-kinases [cytosol] (Mus musculus)
Btk [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P35991 Btk
Gene Names
Btk, Bpk
Chain
initiator methionine:, chain:2-659
Reference Genes
BioGPS Gene:12229 Btk
KEGG:mmu:12229 Btk
Monarch:12229 Btk
NCBI Gene:12229 Btk
UCSC:P35991 Btk
Reference Transcript
RefSeq:XM_006528485.3 Btk
RefSeq:NM_013482.2 Btk
RefSeq:XM_006528484.3 Btk
RefSeq:XM_006528483.3 Btk
Other Identifiers
10606694
12229
1422755_at
17544491
4315801
4316340
4430992
4442988
4508773
4663147
4686834
4762549
4784619
4797869
4802352
4806675
4879789
4888442
4903218
4928896
5013694
5038110
5181212
5246001
5279770
5350754
5375663
5407825
5421704
92668_at
A_51_P145883
A_55_P1953819
A_55_P2158498
GE36959
GO:0001780
GO:0001805
GO:0001812
GO:0001818
GO:0002250
GO:0002344
GO:0002376
GO:0002553
GO:0002639
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005515
GO:0005524
GO:0005547
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0006915
GO:0008289
GO:0012501
GO:0016004
GO:0016740
GO:0030163
GO:0030167
GO:0030889
GO:0030890
GO:0031410
GO:0032496
GO:0032693
GO:0032755
GO:0032760
GO:0034614
GO:0035556
GO:0042802
GO:0043226
GO:0043274
GO:0045087
GO:0045121
GO:0046872
GO:0048469
GO:0048471
GO:0050766
GO:0050852
GO:0050853
GO:0050869
GO:0061516
GO:0070664
GO:0071226
GO:0098542
GO:0098761
GO:0098772
GO:0140096
GO:0150153
GO:1900227
GO:1901135
GO:1901647
GO:1990959
ILMN_1235934
l10627_s_at
mMC007729
Participates
as an output of
Gq-BTK complex dissociates to Active BTK and Gq (Mus musculus)
G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Mus musculus)
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Mus musculus)
as an input of
Active Gq binds BTK (Mus musculus)
G alpha (12) binds BTK (Mus musculus)
G beta-gamma complex and PIP3 recruit BTK to membrane (Mus musculus)
Recruitment of VAV and BTK to p-SLP-76 (Mus musculus)
Lyn, p-Syk phosphorylate Btk (Mus musculus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Mus musculus)
as a component of
Active Gq:BTK [plasma membrane] (Mus musculus)
G alpha (12):BTK [plasma membrane] (Mus musculus)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Mus musculus)
BTK:PIP3 [plasma membrane] (Mus musculus)
as a member of
Tec kinases [cytosol] (Mus musculus)
TEC,BTK,ITK,(TXK) [cytosol] (Mus musculus)
as a candidate of
Src-kinases [cytosol] (Mus musculus)
Other forms of this molecule
p-Y551,Y223-Btk [cytosol]
p-Y551-Btk [cytosol]
phospho-p-Y223,Y551-BTK [plasma membrane]
Inferred From
Active BTK [cytosol]
(Homo sapiens)
BTK [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006528546.1
,
XP_006528547.1
,
NP_038510.2
,
XP_006528548.1
ZINC - Investigational
BTK_MOUSE
ENSEMBL
ENSMUSP00000033617
,
ENSMUST00000033617
IntEnz
2.7.10.2
ZINC - Substances
BTK_MOUSE
ZINC target
P35991
PRO
P35991
MGI
88216
ZINC - Predictions - Purchasable
BTK_MOUSE
PDB
8S93
,
8GMB
,
8S9F
,
8FF0
,
6MNY
,
8FD9
,
4XI2
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.558
2
ChEBI:16337 PHOSPHATIDIC ACIDS
0.558
2
ChEBI:16749 1-PHOSPHATIDYL-1D-MYO-INOSITOL
0.558
2
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE
0.558
2
UniProt:P27512
1
Cd40 [plasma membrane]
(R-MMU-198117)
0.556
3
UniProt:Q80UF7
1
Ticam1 [cytosol]
(R-MMU-166170)
0.499
2
UniProt:P22366
1
Myd88 [cytosol]
(R-MMU-166059)
0.499
2
UniProt:Q9QUN3
2
Blnk [cytosol]
(R-MMU-912750)
phospho-Blnk [plasma membrane]
(R-MMU-983579)
0.463
2
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