Reactome | PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm]

PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm]

Stable Identifier

R-MMU-9918357

Type

Complex

Species

Mus musculus

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G1/S DNA Damage Checkpoints (Mus musculus)
    - p53-Independent G1/S DNA Damage Checkpoint (Mus musculus)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Mus musculus)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - Mitotic G1 phase and G1/S transition (Mus musculus)
    - G1/S Transition (Mus musculus)
      - Cyclin E associated events during G1/S transition (Mus musculus)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)
  - Regulation of mitotic cell cycle (Mus musculus)
    - APC/C-mediated degradation of cell cycle proteins (Mus musculus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Mus musculus)
        
        Degradation of multiubiquitinated Cdh1 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)
  - S Phase (Mus musculus)
    - Cyclin A:Cdk2-associated events at S phase entry (Mus musculus)
      - SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular response to chemical stress (Mus musculus)
    - KEAP1-NFE2L2 pathway (Mus musculus)
      - Nuclear events mediated by NFE2L2 (Mus musculus)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Mus musculus)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)

DNA Replication (Mus musculus)

- DNA Replication Pre-Initiation (Mus musculus)
  - Assembly of the pre-replicative complex (Mus musculus)
    - Ubiquitinated geminin is degraded by the proteasome (Mus musculus)
      - 26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional regulation by RUNX2 (Mus musculus)
      - Regulation of RUNX2 expression and activity (Mus musculus)
        
        26S proteasome degrades PolyUb-RUNX2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)
    - Transcriptional regulation by RUNX3 (Mus musculus)
      - Regulation of RUNX3 expression and activity (Mus musculus)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Hedgehog (Mus musculus)
  - Hedgehog 'on' state (Mus musculus)
    - GLI2,3 are degraded by the proteasome (Mus musculus)
      - 26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as a component of

19S RP Lid Module 1 [nucleoplasm] (Mus musculus)

Inferred From

PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)

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