Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
F2 [extracellular region]
Stable Identifier
R-MMU-140598
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
extracellular region
Synonyms
thrombin light chain, P19221
Locations in the PathwayBrowser
Expand all
Hemostasis (Mus musculus)
Formation of Fibrin Clot (Clotting Cascade) (Mus musculus)
Common Pathway of Fibrin Clot Formation (Mus musculus)
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
factor V -> factor Va + factor V activation peptide (Mus musculus)
Extracellular thrombin inactivating complexes [extracellular region] (Mus musculus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Mus musculus)
Extracellular thrombin inactivating complexes [extracellular region] (Mus musculus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Factor IIa inhibitors:IIa [extracellular region] (Mus musculus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Mus musculus)
Extracellular thrombin inactivating complexes [extracellular region] (Mus musculus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Factor IIa inhibitors:IIa [extracellular region] (Mus musculus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Mus musculus)
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Intrinsic Pathway of Fibrin Clot Formation (Mus musculus)
Factor IIa inhibitors (compounds) binds IIa (Mus musculus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Factor IIa inhibitors (peptide) binds IIa (Mus musculus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Mus musculus)
Extracellular thrombin inactivating complexes [extracellular region] (Mus musculus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Factor IIa inhibitors:IIa [extracellular region] (Mus musculus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Mus musculus)
Extracellular thrombin inactivating complexes [extracellular region] (Mus musculus)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
thrombin:cleaved SERPINC1 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Factor IIa inhibitors:IIa [extracellular region] (Mus musculus)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Platelet Aggregation (Plug Formation) (Mus musculus)
Thrombin binding to GP1b:IX:V (Mus musculus)
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Thrombin signalling through proteinase activated receptors (PARs) (Mus musculus)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Complement cascade (Mus musculus)
Regulation of Complement cascade (Mus musculus)
Thrombin, ELANE cleave C5 (Mus musculus)
Activated thrombin, (ELANE) [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (q) signalling events (Mus musculus)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Mus musculus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
The Ligand:GPCR:Gq complex dissociates (Mus musculus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Mus musculus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Mus musculus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
GPCR ligand binding (Mus musculus)
Class A/1 (Rhodopsin-like receptors) (Mus musculus)
Peptide ligand-binding receptors (Mus musculus)
Proteinase-activated receptors can bind thrombin (Mus musculus)
Thrombin:Proteinase-activated receptors [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
F2 [extracellular region] (Mus musculus)
External Reference Information
External Reference
UniProt:P19221
Gene Names
F2
Reference Genes
BioGPS Gene:14061 F2
ENSEMBL:ENSMUSG00000027249
ENSEMBL:ENSMUSG00000027249.16 F2
KEGG Gene (Mus musculus):14061 F2
Monarch:14061 F2
NCBI Gene:14061 F2
UCSC:P19221 F2
Reference Transcript
RefSeq:NM_010168.3 F2
Other Identifiers
101899_at
10485027
14061
1418897_at
17388234
4475772
4503788
4748088
4862826
4988588
4995415
5051307
5051990
5053192
5075406
5157709
5309172
5350936
5354676
5482740
5583017
5594976
A_51_P480311
A_55_P1960683
GO:0001530
GO:0001934
GO:0002376
GO:0003824
GO:0004175
GO:0004252
GO:0005102
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006508
GO:0006953
GO:0006954
GO:0007166
GO:0007186
GO:0007596
GO:0007599
GO:0008201
GO:0008233
GO:0008236
GO:0008284
GO:0008289
GO:0008360
GO:0009611
GO:0009897
GO:0010468
GO:0016787
GO:0023052
GO:0030154
GO:0030168
GO:0030194
GO:0030307
GO:0030312
GO:0031012
GO:0032024
GO:0032967
GO:0036211
GO:0042060
GO:0042730
GO:0045861
GO:0048712
GO:0048856
GO:0050878
GO:0051281
GO:0051480
GO:0051838
GO:0051897
GO:0055065
GO:0055085
GO:0060089
GO:0061844
GO:0062023
GO:0070053
GO:0070493
GO:0070945
GO:0098542
GO:0140096
GO:1900016
GO:1900182
GO:1900738
GO:1990806
GO:2000379
ILMN_2727396
ILMN_2789786
mMC017879
x52308_s_at
Participates
as a component of
activated thrombin (factor IIa) [extracellular region] (Mus musculus)
Other forms of this molecule
F2 [Golgi lumen]
F2 [Golgi lumen]
F2 [Golgi lumen]
F2 [endoplasmic reticulum lumen]
F2 [endoplasmic reticulum lumen]
F2 [extracellular region]
F2 [extracellular region]
F2 [plasma membrane]
F2 [plasma membrane]
F2 [extracellular region]
Inferred From
thrombin light chain [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_034298.1
OpenTargets
ENSG00000180210
ZINC - Substances
THRB_MOUSE
ZINC target
P19221
Ensembl
ENSMUSG00000027249
,
ENSMUSP00000028681
,
ENSMUST00000028681
PRO
P19221
MGI
88380
ZINC - Predictions - Purchasable
THRB_MOUSE
PDB
2PUX
,
3EDX
,
2OCV
,
2PV9
,
3HK3
,
3HKI
,
3HK6
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text