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F2 [plasma membrane]
Stable Identifier
R-MMU-140809
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
plasma membrane
Synonyms
thrombin heavy chain, P19221
Locations in the PathwayBrowser
Expand all
Hemostasis (Mus musculus)
Cell surface interactions at the vascular wall (Mus musculus)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Mus musculus)
activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
F2 [plasma membrane] (Mus musculus)
activated thrombin:thrombomodulin [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
F2 [plasma membrane] (Mus musculus)
Formation of Fibrin Clot (Clotting Cascade) (Mus musculus)
Common Pathway of Fibrin Clot Formation (Mus musculus)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Mus musculus)
activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
F2 [plasma membrane] (Mus musculus)
activated thrombin:thrombomodulin [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
F2 [plasma membrane] (Mus musculus)
Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin (Mus musculus)
SERPINE2:GAG:activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
F2 [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
F2 [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Mus musculus)
thrombin:SERPINC1:SERPINC1 activators [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
F2 [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Mus musculus)
activated thrombin:thrombomodulin [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
F2 [plasma membrane] (Mus musculus)
factor V -> factor Va + factor V activation peptide (Mus musculus)
SERPINE2:GAG:activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
F2 [plasma membrane] (Mus musculus)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Mus musculus)
SERPINE2:GAG:activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
F2 [plasma membrane] (Mus musculus)
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Mus musculus)
activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
F2 [plasma membrane] (Mus musculus)
thrombin:SERPINC1:SERPINC1 activators [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
F2 [plasma membrane] (Mus musculus)
thrombin:cleaved SERPINC1:SERPINC1 activators [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
F2 [plasma membrane] (Mus musculus)
thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Mus musculus)
thrombin:cleaved SERPINC1:SERPINC1 activators [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
F2 [plasma membrane] (Mus musculus)
Intrinsic Pathway of Fibrin Clot Formation (Mus musculus)
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Mus musculus)
SERPINE2:GAG:activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
F2 [plasma membrane] (Mus musculus)
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Mus musculus)
SERPINE2:GAG:activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
F2 [plasma membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:P19221
Gene Names
F2
Reference Genes
BioGPS Gene:14061 F2
ENSEMBL:ENSMUSG00000027249
ENSEMBL:ENSMUSG00000027249.16 F2
KEGG Gene (Mus musculus):14061 F2
Monarch:14061 F2
NCBI Gene:14061 F2
UCSC:P19221 F2
Reference Transcript
RefSeq:NM_010168.3 F2
Other Identifiers
101899_at
10485027
14061
1418897_at
17388234
4475772
4503788
4748088
4862826
4988588
4995415
5051307
5051990
5053192
5075406
5157709
5309172
5350936
5354676
5482740
5583017
5594976
A_51_P480311
A_55_P1960683
GO:0001530
GO:0001934
GO:0002376
GO:0003824
GO:0004175
GO:0004252
GO:0005102
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006508
GO:0006953
GO:0006954
GO:0007166
GO:0007186
GO:0007596
GO:0007599
GO:0008201
GO:0008233
GO:0008236
GO:0008284
GO:0008289
GO:0008360
GO:0009611
GO:0009897
GO:0010468
GO:0016787
GO:0023052
GO:0030154
GO:0030168
GO:0030194
GO:0030307
GO:0030312
GO:0031012
GO:0032024
GO:0032967
GO:0036211
GO:0042060
GO:0042730
GO:0045861
GO:0048712
GO:0048856
GO:0050878
GO:0051281
GO:0051480
GO:0051838
GO:0051897
GO:0055065
GO:0055085
GO:0060089
GO:0061844
GO:0062023
GO:0070053
GO:0070493
GO:0070945
GO:0098542
GO:0140096
GO:1900016
GO:1900182
GO:1900738
GO:1990806
GO:2000379
ILMN_2727396
ILMN_2789786
mMC017879
x52308_s_at
Participates
as a component of
activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
Other forms of this molecule
F2 [Golgi lumen]
F2 [Golgi lumen]
F2 [Golgi lumen]
F2 [endoplasmic reticulum lumen]
F2 [endoplasmic reticulum lumen]
F2 [extracellular region]
F2 [extracellular region]
F2 [plasma membrane]
F2 [extracellular region]
F2 [extracellular region]
Inferred From
thrombin heavy chain [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_034298.1
OpenTargets
ENSG00000180210
ZINC - Substances
THRB_MOUSE
ZINC target
P19221
Ensembl
ENSMUSG00000027249
,
ENSMUSP00000028681
,
ENSMUST00000028681
PRO
P19221
MGI
88380
ZINC - Predictions - Purchasable
THRB_MOUSE
PDB
2PUX
,
3EDX
,
2OCV
,
2PV9
,
3HK3
,
3HKI
,
3HK6
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