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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
DOIs
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ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
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How do I search ?
Details Panel
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Lyn [cytosol]
Stable Identifier
R-MMU-1112642
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Tyrosine-protein kinase Lyn, LYN_MOUSE, Lyn
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
EPH-Ephrin signaling (Mus musculus)
EPH-ephrin mediated repulsion of cells (Mus musculus)
EPHA binds TIAM1 (Mus musculus)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Mus musculus)
SRC,FYN,YES,LYN [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Mus musculus)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Mus musculus)
SRC,FYN,YES,LYN [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
SFKs phosphorylate VAV2,3 (Mus musculus)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Mus musculus)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
SRC,FYN,YES,LYN [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Mus musculus)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
SRC,FYN,YES,LYN [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
SRC,FYN,YES,LYN [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Mus musculus)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Mus musculus)
SRC,FYN,YES,LYN [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Mus musculus)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
SRC,FYN,YES,LYN [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
p-EPHs bind VAV2,3 (Mus musculus)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Mus musculus)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
SRC,FYN,YES,LYN [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Mus musculus)
SRC,FYN,YES,LYN [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EPHA-mediated growth cone collapse (Mus musculus)
NGEF exchanges GTP for GDP on RHOA (Mus musculus)
EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Mus musculus)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Mus musculus)
SRC,FYN,YES,LYN [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EPHB-mediated forward signaling (Mus musculus)
EPHB phosphorylates TIAM1 (Mus musculus)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Mus musculus)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Mus musculus)
EFNBs:p-EPHBs:SFKs [plasma membrane] (Mus musculus)
SRC,FYN,YES,LYN [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Mus musculus)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Mus musculus)
EFNBs:p-EPHBs:SFKs [plasma membrane] (Mus musculus)
SRC,FYN,YES,LYN [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EPHB:NMDAR binds TIAM1 (Mus musculus)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Mus musculus)
EFNBs:p-EPHBs:SFKs [plasma membrane] (Mus musculus)
SRC,FYN,YES,LYN [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Mus musculus)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Mus musculus)
EFNBs:p-EPHBs:SFKs [plasma membrane] (Mus musculus)
SRC,FYN,YES,LYN [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Mus musculus)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Mus musculus)
EFNBs:p-EPHBs:SFKs [plasma membrane] (Mus musculus)
SRC,FYN,YES,LYN [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Hemostasis (Mus musculus)
Cell surface interactions at the vascular wall (Mus musculus)
Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Mus musculus)
GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
PECAM1 interactions (Mus musculus)
Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Platelet Adhesion to exposed collagen (Mus musculus)
Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Mus musculus)
GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
GPVI binds Fyn and Lyn (Mus musculus)
GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
GPVI-mediated activation cascade (Mus musculus)
Binding of Syk tyrosine kinase (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Mus musculus)
GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
GPVI stimulates PI3K beta, gamma (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
SYK autophosphorylates (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
p-Y348-SYK dissociates (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Regulation of T cell activation by CD28 family (Mus musculus)
Co-inhibition by CTLA4 (Mus musculus)
Phosphorylation of CTLA-4 (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
SHP2 phosphatase binds CTLA-4 (Mus musculus)
p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Mus musculus)
p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Co-stimulation by CD28 (Mus musculus)
Phosphorylation of CD28 (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Growth hormone receptor signaling (Mus musculus)
Lyn activates ERK (Mus musculus)
Growth Hormone:Growth Hormone Receptor-JAK2 dimer:LYN [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
Regulation of signaling by CBL (Mus musculus)
CBL ubiquitinates PI3K (Mus musculus)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
FYN-like kinases [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
FYN-like kinases [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Mus musculus)
FYN-like kinases [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Mus musculus)
FYN-like kinases [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CD209 (DC-SIGN) signaling (Mus musculus)
SFKs phosphorylates RAF1 on Y340,Y341 (Mus musculus)
FYN, LYN [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Dectin-2 family (Mus musculus)
LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Mus musculus)
FYN, LYN [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
FCGR activation (Mus musculus)
Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Mus musculus)
Src family kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Erythropoietin (Mus musculus)
EPOR binds EPOR agonists (Mus musculus)
EPOR agonists:EPOR:JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
EPOR:JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EPOR:JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Mus musculus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI3K bound to EPOR [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Erythropoietin activates RAS (Mus musculus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by SCF-KIT (Mus musculus)
Dimerization of STATs (Mus musculus)
p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Disassociation and translocation of STATs to the nucleus (Mus musculus)
p-JAK2:SFKs:p-KIT complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
GRB2 is indirectly recruited to p-KIT through SHP2 (Mus musculus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Indirect recruitment of GAB2 to p-KIT (Mus musculus)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Mus musculus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
JAK2 binds to p-KIT (Mus musculus)
JAK2:SFKS:p-KIT complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Phosphorylation and activation of VAV1 (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Phosphorylation of GAB2 by SFKs (Mus musculus)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Phosphorylation of JAK2 (Mus musculus)
JAK2:SFKS:p-KIT complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
p-JAK2:SFKs:p-KIT complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Phosphorylation of SHP2 by SFKs (Mus musculus)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Phosphorylation of STATs (Mus musculus)
p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Phosphorylation of p-KIT on Y900 by Src kinases (Mus musculus)
SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Recruitment of STATs (Mus musculus)
p-JAK2:SFKs:p-KIT complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Regulation of KIT signaling (Mus musculus)
Interaction of APS and p-KIT (Mus musculus)
APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Phosphorylation of APS (Mus musculus)
APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
p-APS dimer:p-KIT complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Recruitment of CBL to KIT (Mus musculus)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Mus musculus)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Mus musculus)
p-APS dimer:p-KIT complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Mus musculus)
p-APS dimer:p-KIT complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
SHP2 interacts with p-KIT (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
Synthesis of PIP3 from PIP2 by PI3K (Mus musculus)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
SFKs:p-KIT complex [plasma membrane] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P25911 Lyn
Gene Names
Lyn
Chain
initiator methionine:, chain:2-512
Reference Genes
BioGPS Gene:17096 Lyn
KEGG:mmu:17096 Lyn
Monarch:17096 Lyn
NCBI Gene:17096 Lyn
UCSC:P25911 Lyn
Reference Transcript
RefSeq:NM_001111096.1 Lyn
Other Identifiers
103349_at
10503098
1425598_a_at
1451318_a_at
17096
17411527
4359503
4421465
4450241
4514955
4539095
4542987
4654443
4711845
4753338
4831594
4838769
4871962
4899244
4948508
5000816
5042646
5062427
5142854
5164549
5187950
5242924
5342503
5390835
5417468
5426646
5497860
5502994
5573531
A_51_P345422
A_52_P34823
A_55_P1958088
A_55_P2723944
A_65_P04064
GE32953
GO:0000077
GO:0001782
GO:0001817
GO:0001933
GO:0002244
GO:0002250
GO:0002376
GO:0002431
GO:0002513
GO:0002553
GO:0002576
GO:0002762
GO:0002768
GO:0002774
GO:0002902
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005102
GO:0005128
GO:0005161
GO:0005178
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0005912
GO:0006468
GO:0006954
GO:0006974
GO:0006991
GO:0007169
GO:0008092
GO:0008284
GO:0008285
GO:0008289
GO:0009410
GO:0009636
GO:0009725
GO:0009743
GO:0009898
GO:0010976
GO:0014003
GO:0014070
GO:0015908
GO:0016192
GO:0016740
GO:0017124
GO:0018108
GO:0019899
GO:0030061
GO:0030097
GO:0030154
GO:0030218
GO:0030222
GO:0030335
GO:0030889
GO:0031175
GO:0031625
GO:0031663
GO:0031966
GO:0032868
GO:0032991
GO:0033003
GO:0033628
GO:0034136
GO:0034142
GO:0034144
GO:0034605
GO:0034666
GO:0035556
GO:0038043
GO:0038159
GO:0042327
GO:0042541
GO:0043015
GO:0043200
GO:0043208
GO:0043226
GO:0043231
GO:0043304
GO:0043407
GO:0043410
GO:0043434
GO:0044325
GO:0044877
GO:0045087
GO:0045121
GO:0045646
GO:0046777
GO:0046875
GO:0048471
GO:0048678
GO:0048856
GO:0050727
GO:0050853
GO:0050855
GO:0051219
GO:0051279
GO:0060252
GO:0060369
GO:0070372
GO:0070373
GO:0070447
GO:0070667
GO:0070668
GO:0071300
GO:0090025
GO:0090330
GO:0097028
GO:0097110
GO:0098542
GO:0098772
GO:0098978
GO:0099091
GO:0140031
GO:0140096
GO:0141038
GO:1902532
GO:2000670
ILMN_2596887
Msa.920.0_f_at
m57696_f_at
mMC007755
Participates
as a component of
Lyn:p-Y-Inpp5d [cytosol] (Mus musculus)
Growth hormone:Tyrosine phosphorylated growth hormone receptor-p-Jak2 dimer:Lyn [plasma membrane] (Mus musculus)
Growth Hormone:Growth Hormone Receptor-JAK2 dimer:LYN [plasma membrane] (Mus musculus)
p-4Y-Csf3r:p-Y-Jak1:Lyn [endocytic vesicle membrane] (Mus musculus)
p-4Y-Csf3r:p-Y-Jak1:Lyn [plasma membrane] (Mus musculus)
Csf3r:p-Y-Jak1:Lyn [plasma membrane] (Mus musculus)
Csf3r:Jak1:Lyn [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 [plasma membrane] (Mus musculus)
Epor:p-12Y-Jak2:Lyn:Irs2 [plasma membrane] (Mus musculus)
Epor:Jak2:Lyn:Irs2 [plasma membrane] (Mus musculus)
EPOR:JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Mus musculus)
GPVI:FceRI gamma:FYN:LYN [plasma membrane] (Mus musculus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Mus musculus)
as an input of
Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated (Mus musculus)
Growth hormone receptor binds Lyn (Mus musculus)
GPVI binds Fyn and Lyn (Mus musculus)
as a candidate of
FYN-like kinases [cytosol] (Mus musculus)
as a member of
FYN, LYN [cytosol] (Mus musculus)
SRC,FYN,YES,LYN [cytosol] (Mus musculus)
Src family kinases (SFKs) [cytosol] (Mus musculus)
Src family tyrosine kinases (SFKs) [cytosol] (Mus musculus)
Lyn, p-Syk [cytosol] (Mus musculus)
Src family kinases (SFKs) [cytosol] (Mus musculus)
Other forms of this molecule
MyrG2-PalmC3-LYN [lysosomal membrane]
MyrG2-PalmC3-LYN [endocytic vesicle membrane]
LYN [plasma membrane]
phospho-p-Y397-LYN [cytosol]
phospho-p-Y397-LYN [plasma membrane]
MyrG2-PalmC3-LYN [plasma membrane]
Inferred From
LYN [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001104566.1
ENSEMBL
ENSMUST00000041377
,
ENSMUST00000103010
,
ENSMUSP00000100075
,
ENSMUSP00000038838
ZINC - Substances
LYN_MOUSE
ZINC target
P25911
PRO
P25911
GlyGen
P25911
MGI
96892
ZINC - Predictions - Purchasable
LYN_MOUSE
HMDB Protein
HMDBP13813
PDB
2ZV8
,
2ZV7
,
4TZI
,
2ZVA
,
2ZV9
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49710 HCLS1
0.696
11
UniProt:Q8CIH5 Plcg2
9
p-Y-Plcg2 [cytosol]
(R-MMU-9029100)
p-Y753,Y759-Plcg2 [cytosol]
(R-MMU-5607654)
phospho-Plcg2 [cytosol]
(R-MMU-5607631)
phospho-Plcg2 [plasma membrane]
(R-MMU-5607640)
phospho-Plcg2 [plasma membrane]
(R-MMU-2685601)
Plcg2 [cytosol]
(R-MMU-5607628)
phospho-Plcg2 [plasma membrane]
(R-MMU-984816)
Plcg2 [plasma membrane]
(R-MMU-114601)
phospho-Plcg2 [plasma membrane]
(R-MMU-114602)
0.524
2
UniProt:Q64355 EFS
0.521
2
UniProt:Q9Z1S8 Gab2
8
phospho-Gab2 [cytosol]
(R-MMU-9677149)
phospho-Gab2 [cytosol]
(R-MMU-8855574)
p-Y-Gab2 [cytosol]
(R-MMU-9007111)
p-3Y-Gab2 [cytosol]
(R-MMU-2685633)
Gab2 [cytosol]
(R-MMU-2685613)
Gab2 [cytosol]
(R-MMU-508239)
phospho-Gab2 [cytosol]
(R-MMU-2685615)
phospho-Gab2 [cytosol]
(R-MMU-912529)
0.499
2
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