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phospho-Gab2 [cytosol]
Stable Identifier
R-MMU-912529
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
p-Y-GAB2, Q9Z1S8
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
FLT3 Signaling (Mus musculus)
Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Mus musculus)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Mus musculus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Mus musculus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Mus musculus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-2 family signaling (Mus musculus)
Interleukin receptor SHC signaling (Mus musculus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Mus musculus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
Interleukin receptor SHC signaling (Mus musculus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Mus musculus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Mus musculus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Mus musculus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Mus musculus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Mus musculus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI3K-containing complexes [cytosol] (Mus musculus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Mus musculus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
Signaling by SCF-KIT (Mus musculus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Mus musculus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
Phosphorylation of GAB2 by SFKs (Mus musculus)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
Synthesis of PIP3 from PIP2 by PI3K (Mus musculus)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Mus musculus)
IGF1R signaling cascade (Mus musculus)
IRS-related events triggered by IGF1R (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI3K-containing complexes [cytosol] (Mus musculus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Mus musculus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Mus musculus)
phospho-Gab2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9Z1S8 Gab2
Gene Names
Gab2
Chain
chain:1-665
Participates
as a component of
GRB2:p-Y-GAB2 [cytosol] (Mus musculus)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Mus musculus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Mus musculus)
Other forms of this molecule
phospho-Gab2 [cytosol]
phospho-Gab2 [cytosol]
p-Y-Gab2 [cytosol]
p-3Y-Gab2 [cytosol]
Gab2 [cytosol]
Gab2 [cytosol]
phospho-Gab2 [cytosol]
Inferred From
p-Y-GAB2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
PRO
Q9Z1S8
MGI
1333854
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P25911 Lyn
7
MyrG2-PalmC3-LYN [lysosomal membrane]
(R-MMU-9707903)
MyrG2-PalmC3-LYN [endocytic vesicle membrane]
(R-MMU-9705728)
LYN [plasma membrane]
(R-MMU-197943)
phospho-p-Y397-LYN [cytosol]
(R-MMU-8942608)
phospho-p-Y397-LYN [plasma membrane]
(R-MMU-2454229)
MyrG2-PalmC3-LYN [plasma membrane]
(R-MMU-9606875)
Lyn [cytosol]
(R-MMU-1112642)
0.499
2
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