LNK binds to p-KIT and inhibit downstream signaling

Stable Identifier
R-HSA-1562640
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region, cytosol
ReviewStatus
5/5
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LNK binds to p-KIT and inhibit downstream signaling
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The adaptor protein LNK with its SH2 domain binds to the juxtamembrane domain (amino acids 544-577) of KIT on Y568 and inhibit the downstream signalling (Gueller et al. 2008).
Literature References
PubMed ID Title Journal Year
18588518 Adaptor protein Lnk associates with Tyr(568) in c-Kit

Gery, S, Nowak, V, Koeffler, HP, Gueller, S, Serve, H, Liu, L

Biochem J 2008
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Orthologous Events
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LNK binds to p-KIT and inhibit downstream signaling (Mus musculus)
LNK binds to p-KIT and inhibit downstream signaling (Sus scrofa)
LNK binds to p-KIT and inhibit downstream signaling (Xenopus tropicalis)
Authored
Garapati, P V  (2011-07-11)
Reviewed
Rönnstrand, L  (2011-08-22)
Created
Garapati, P V  (2011-09-05)
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