Unknown ALDH oxidizes 3-AAPNAL

Stable Identifier
R-HSA-9971446
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Unknown ALDH oxidizes 3-AAPNAL
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
An unspecified aldehyde dehydrogenase catalyzes the oxidation of 3-acetamidopropanal (3-AAPNAL) to N-acetyl-beta-alaninate, which is secreted (Wu et al., 2017). We infer this reaction from the existence of the product and the educt, and the existence of analogous reactions (Ambroziak et al., 1991; Riveros-Rosas et al., 2012).
Literature References
PubMed ID Title Journal Year
28694431 Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes

Wu, W, Bush, KT, Nigam, SK

Sci Rep 2017
1799975 Aldehyde dehydrogenase (EC 1.2.1.3): comparison of subcellular localization of the third isozyme that dehydrogenates gamma-aminobutyraldehyde in rat, guinea pig and human liver

Ambroziak, W, Kurys, G, Pietruszko, R

Comp Biochem Physiol B 1991
23219887 Structural determinants of substrate specificity in aldehyde dehydrogenases

Riveros-Rosas, H, González-Segura, L, Julián-Sánchez, A, Díaz-Sánchez, AG, Muñoz-Clares, RA

Chem Biol Interact 2013
Participants
Input
Output
Participates
as an event of
Catalyst Activity

aldehyde dehydrogenase (NAD+) activity of Unknown aldehyde dehydrogenase [cytosol]

Physical Entity
Unknown aldehyde dehydrogenase [cytosol] (Homo sapiens)
Activity
aldehyde dehydrogenase (NAD+) activity (GO:0004029)
Cross References
RHEA
Authored
Stephan, R  (2025-11-06)
Reviewed
D'Eustachio, P  (2026-02-10)
Created
Stephan, R  (2025-11-06)
Cite Us!