Reactome | TM7SF2 reduces 4,4-diMeCholesta-8,14-dien-3-ol to 4,4-diMe5-cholest-8-en-3-ol

TM7SF2 reduces 4,4-diMeCholesta-8,14-dien-3-ol to 4,4-diMe5-cholest-8-en-3-ol

Stable Identifier

R-HSA-9946140

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

Synonyms

4,4-dimethyl-8,14-cholestadien-3beta-ol + NADPH + H(+) => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

TM7SF2 reduces 4,4-diMeCholesta-8,14-dien-3-ol to 4,4-diMe5-cholest-8-en-3-ol

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TM7SF2 (Delta(14)-sterol reductase Transmembrane 7 superfamily member 2), localized to the endoplasmic reticulum membrane, reduces 4,4-diMeCholesta-8,14-dien-3-ol to 4,4-diMe-5-cholest-8-en-3-ol (Bennati et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16784888	Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis Bennati, AM, Castelli, M, Della Fazia, MA, Beccari, T, Caruso, D, Servillo, G, Roberti, R	Biochim Biophys Acta	2006