Reactome | HSD17B7 reduces 5a-cholest-8-en-3-one to ZYMSTNL

HSD17B7 reduces 5a-cholest-8-en-3-one to ZYMSTNL

Stable Identifier

R-HSA-9945804

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

Synonyms

5alpha-cholest-8-en-3-one + NADPH + H(+) => 5alpha-cholest-8-en-3beta-ol + NADP(+)

ReviewStatus

5/5

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HSD17B7 reduces 5a-cholest-8-en-3-one to ZYMSTNL

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HSD17B7 (3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7), in the endoplasmic reticulum membrane, reduces 5alpha-cholest-8-en-3-one to ZYMSTNL (zymostenol, 5alpha-cholest-8-en-3beta-ol) (Marijanovic et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12829805	Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis Marijanovic, Z, Laubner, D, Moller, G, Gege, C, Husen, B, Adamski, J, Breitling, R	Mol. Endocrinol.	2003