p-STAT1 and NFATC1 bind the TBX21 gene

Stable Identifier
R-HSA-9942683
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p-STAT1 and NFATC1 bind the TBX21 gene
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STAT1 and NFATC1 bind the conserved noncoding region 12 (CSR 12) of the TBX21 (T-bet) gene (inferred from mouse homologs in Zhong et al. 2025). TBX21 expression is initiated by IFNG signaling via STAT1 (inferred from mouse homologs in Lighvani et al. 2001, Afkarian et al. 2002) phosphorylated on serine 727 (inferred from the mouse homolog in Maldonado et al. 2009) and by TCR signaling via STIM1, calcium signaling, and NFATC1 (inferred from mouse homologs in Zhong et al. 2025). TBX21 then activates expression of the IL21 receptor subunit IL21RB2, allowing maintenance of TBX21 expression by IL21 acting via IL21RB2 and STAT4.
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Inferred From
Stat1 and Nfatc1 bind the Tbx21 (T-bet) gene (Mus musculus)
Authored
May, B  (2025-03-17)
Reviewed
Barbutti, I  (2025-08-04)
Lord, GM  (2025-08-05)
Created
May, B  (2025-03-19)
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