SMARCA4, BCL11A,B-containing ATPase module binds SMARCC1:SMACC2 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1A:DPF2, PHF10

Stable Identifier
R-HSA-9934024
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
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The ATPase module of the esBAF complex contains SMARCA4/BRG1 to the exclusion of SMARCA2/BRM (Zhang et al, 2014; Ho et al, 2009; reviewed in Kadoch and Crabtree, 2015; Innis and Cabot, 2020 Cenik and Shilatifard, 2021). Like the cBAF and ncBAF, esBAF also contains the SS18 subunit, and is additionally characterized by the inclusion of either BCL11A or BCL11B. Whether BCL11A and B are unique to esBAF or are also components of cBAF is not clear (Kadoch et al, 2013; Mashtalir et al, 2018; Mashtalir et al, 2020; reviewed in Kadoch and Crabtree, 2015; Innis and Cabot, 2020; Cenik and Shilatifard, 2021).
Literature References
PubMed ID Title Journal Year
25241744 Transcriptional repression by the BRG1-SWI/SNF complex affects the pluripotency of human embryonic stem cells

Zhang, X, Li, B, Li, W, Ma, L, Zheng, D, Li, L, Yang, W, Chu, M, Chen, W, Mailman, RB, Zhu, J, Fan, G, Archer, TK, Wang, Y

Stem Cell Reports 2014
33053319 A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms

Mashtalir, N, Suzuki, H, Farrell, DP, Sankar, A, Luo, J, Filipovski, M, D'Avino, AR, St Pierre, R, Valencia, AM, Onikubo, T, Roeder, RG, Han, Y, He, Y, Ranish, JA, Dimaio, F, Walz, T, Kadoch, C

Cell 2020
32958894 COMPASS and SWI/SNF complexes in development and disease

Cenik, BK, Shilatifard, A

Nat Rev Genet 2021
26601204 Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics

Kadoch, C, Crabtree, GR

Sci Adv 2015
33143733 GBAF, a small BAF sub-complex with big implications: a systematic review

Innis, SM, Cabot, B

Epigenetics Chromatin 2020
19279220 An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency

Ho, L, Ronan, JL, Wu, J, Staahl, BT, Chen, L, Kuo, A, Lessard, J, Nesvizhskii, AI, Ranish, J, Crabtree, GR

Proc Natl Acad Sci U S A 2009
30343899 Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes

Mashtalir, N, D'Avino, AR, Michel, BC, Luo, J, Pan, J, Otto, JE, Zullow, HJ, McKenzie, ZM, Kubiak, RL, St Pierre, R, Valencia, AM, Poynter, SJ, Cassel, SH, Ranish, JA, Kadoch, C

Cell 2018
23644491 Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

Kadoch, C, Hargreaves, DC, Hodges, C, Elias, L, Ho, L, Ranish, J, Crabtree, GR

Nat Genet 2013
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