Reactome | Formation of neuronal progenitor BAF (npBAF)

Formation of neuronal progenitor BAF (npBAF)

Stable Identifier

R-HSA-9934021

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Formation of neuronal progenitor BAF (npBAF)

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Studies in mice identified a neural progenitor (np) BAF complex that is required for the proliferation of neural stem and progenitor cells (Lessard et al, 2007; Staahl et al, 2013). These complexes differ slightly from esBAF complexes in subunit composition. npBAF complexes contain either SMARCA4 or SMARCA2 as catalytic subunits, may contain either ARID1A or ARID1B, and contain SMARCD1 and SMARCD3 but not SMARCD2 (Lessard et al, 2007; Stahl et al, 2013; reviewed in Staahl and Crabtree, 2013; Kadoch and Crabtree, 2015; Cenik and Shilatifard, 2021; Innis and Cabot, 2020).

Literature References

PubMed ID	Title	Journal	Year
17640523	An essential switch in subunit composition of a chromatin remodeling complex during neural development Lessard, J, Wu, JI, Ranish, JA, Wan, M, Winslow, MM, Staahl, BT, Wu, H, Aebersold, R, Graef, IA, Crabtree, GR	Neuron	2007
24090879	Creating a neural specific chromatin landscape by npBAF and nBAF complexes Staahl, BT, Crabtree, GR	Curr Opin Neurobiol	2013
32958894	COMPASS and SWI/SNF complexes in development and disease Cenik, BK, Shilatifard, A	Nat Rev Genet	2021
26601204	Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics Kadoch, C, Crabtree, GR	Sci Adv	2015
33143733	GBAF, a small BAF sub-complex with big implications: a systematic review Innis, SM, Cabot, B	Epigenetics Chromatin	2020
23785148	Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways Staahl, BT, Tang, J, Wu, W, Sun, A, Gitler, AD, Yoo, AS, Crabtree, GR	J Neurosci	2013