EmrE dimer exports xenobiotics to periplasm

Stable Identifier
R-HSA-9931565
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Escherichia coli
Compartment
plasma membrane
ReviewStatus
3/5
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EmrE dimer exports xenobiotics to periplasm
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E.coli EmrE dimer transports molecules of polyaromatic cation type from the bacterial cytosol to the periplasm, by a coupled 2-proton antiport mechanism. Transported molecules include cationic antiseptics like ethidium, benzalkonium or acriflavinium ions, as well as the aminoglycoside antibiotics streptomycin and tobramycin (Purewal et al., 1990; Morimyo et al., 1992; reviewed in Henzler-Wildman, 2011; Tong et al., 2021).
Literature References
PubMed ID Title Journal Year
1320256 Cloning and characterization of the mvrC gene of Escherichia coli K-12 which confers resistance against methyl viologen toxicity

Morimyo, M, Hongo, E, Hama-Inaba, H, Machida, I

Nucleic Acids Res 1992
33617866 Disinfectant resistance in bacteria: Mechanisms, spread, and resolution strategies

Tong, C, Hu, H, Chen, G, Li, Z, Li, A, Zhang, J

Environ Res 2021
2185131 Cloning of the ethidium efflux gene from Escherichia coli

Purewal, AS, Jones, IG, Midgley, M

FEMS Microbiol Lett 1990
22100111 Analyzing conformational changes in the transport cycle of EmrE

Henzler-Wildman, K

Curr Opin Struct Biol 2012
Participants
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Output
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as an event of
Catalyst Activity

xenobiotic transmembrane transporter activity of EmrE dimer [plasma membrane]

Physical Entity
EmrE dimer [plasma membrane] (Escherichia coli)
Activity
xenobiotic transmembrane transporter activity (GO:0042910)
Disease
Cross References
Mondo
Authored
Stephan, R  (2024-12-11)
Created
Stephan, R  (2024-12-12)
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