MITF-M-dependent SERPINE1 gene expression

Stable Identifier
R-HSA-9926525
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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MITF-M-dependent SERPINE1 gene expression
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SERPINE1, also known as Plasminogen activator inhibitor I (PAI-1), is a serine protease inhibitor with canonical roles in fibrinolysis (reviewed in Morrow and Mutch, 2023). More recently, roles for SERPINE1 have been identified in extracellular matrix remodeling, tumor cell invasion and migration independent of its protease activity (Kjoeller et al, 1997; Degryse et al, 2004; reviewed in Pavon et al, 2016). SERPINE1 inhibits the formation of plasmin at the plasma membrane, restricting the plasmin-dependent degradation of the ECM (reviewed in Pavon et al, 2016).
SERPINE1 has been identified as a direct target of MITF-M-dependent regulation in melanoma cells by ChIP-seq, CUT-and-RUN DNA binding analysis and CRISPR- and si/shRNA-mediated MITF-M knockdown (Dilshat et al, 2021; Webster et al, 2014; Laurette et al, 2015).
Literature References
PubMed ID Title Journal Year
15001579 The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1

Degryse, B, Neels, JG, Czekay, RP, Aertgeerts, K, Kamikubo, Y, Loskutoff, DJ

J Biol Chem 2004
9168821 Plasminogen activator inhibitor-1 represses integrin- and vitronectin-mediated cell migration independently of its function as an inhibitor of plasminogen activation

Kjøller, L, Kanse, SM, Kirkegaard, T, Rodenburg, KW, Rønne, E, Goodman, SL, Preissner, KT, Ossowski, L, Andreasen, PA

Exp Cell Res 1997
25803486 Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

Laurette, P, Strub, T, Koludrovic, D, Keime, C, Le Gras, S, Seberg, H, Van Otterloo, E, Imrichova, H, Siddaway, R, Aerts, S, Cornell, RA, Mengus, G, Davidson, I

Elife 2015
33438577 MITF reprograms the extracellular matrix and focal adhesion in melanoma

Dilshat, R, Fock, V, Kenny, C, Gerritsen, I, Lasseur, RMJ, Travnickova, J, Eichhoff, OM, Cerny, P, Möller, K, Sigurbjornsdottir, S, Kirty, K, Einarsdottir, BO, Cheng, PF, Levesque, M, Cornell, RA, Patton, EE, Larue, L, de Tayrac, M, Magnusdottir, E, Ogmundsdottir, MH, Steingrímsson, E

Elife 2021
24443471 Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition

Webster, DE, Barajas, B, Bussat, RT, Yan, KJ, Neela, PH, Flockhart, RJ, Kovalski, J, Zehnder, A, Khavari, PA

Genome Res 2014
36522166 Past, Present, and Future Perspectives of Plasminogen Activator Inhibitor 1 (PAI-1)

Morrow, GB, Mutch, NJ

Semin Thromb Hemost 2023
27385000 uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy

Pavón, MA, Arroyo-Solera, I, Céspedes, MV, Casanova, I, León, X, Mangues, R

Oncotarget 2016
Participants
Input
Output
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as an event of
This event is regulated
Negatively by
Regulator
MITF-M dimer:SERPINE gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
Authored
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Reviewed
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-11-01)
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