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SERPINE1 gene [nucleoplasm]
Stable Identifier
R-HSA-2106592
Type
DNA Sequence [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Circadian clock (Homo sapiens)
BMAL1:CLOCK,NPAS2 activates circadian expression (Homo sapiens)
Expression of SERPINE1 (PAI-1) (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
p-BMAL1:p-CLOCK,NPAS2:SERPINE1 gene [nucleoplasm] (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
p-BMAL1:p-CLOCK,NPAS2 binds SERPINE1 gene (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
p-BMAL1:p-CLOCK,NPAS2:SERPINE1 gene [nucleoplasm] (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition (Homo sapiens)
MITF-M binds SERPINE1 gene (Homo sapiens)
MITF-M dimer:SERPINE gene [nucleoplasm] (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
MITF-M-dependent SERPINE1 gene expression (Homo sapiens)
MITF-M dimer:SERPINE gene [nucleoplasm] (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 targets host intracellular signalling and regulatory pathways (Homo sapiens)
SARS-CoV-1 N binds SMAD3 and EP300 at the SERPINE1 gene promoter (Homo sapiens)
SARS-CoV-1 N:p-2S-SMAD3:SP1:EP300:SERPINE1 gene [nucleoplasm] (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
SMAD7 binds SERPINE1 gene promoter (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
SMAD7:SERPINE1 gene [nucleoplasm] (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4:SERPINE1 gene [nucleoplasm] (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
SMAD7:SERPINE1 gene [nucleoplasm] (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4:SERPINE1 gene [nucleoplasm] (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
SMAD7 binds SERPINE1 gene promoter (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
SMAD7:SERPINE1 gene [nucleoplasm] (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4:SERPINE1 gene [nucleoplasm] (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
SMAD7:SERPINE1 gene [nucleoplasm] (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4:SERPINE1 gene [nucleoplasm] (Homo sapiens)
SERPINE1 gene [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
ENSEMBL:ENSG00000106366 SERPINE1
Gene Names
SERPINE1, PAI1, PLANH1
Participates
as an input of
MITF-M binds SERPINE1 gene (Homo sapiens)
MITF-M-dependent SERPINE1 gene expression (Homo sapiens)
Expression of SERPINE1 (PAI-1) (Homo sapiens)
p-BMAL1:p-CLOCK,NPAS2 binds SERPINE1 gene (Homo sapiens)
SARS-CoV-1 N binds SMAD3 and EP300 at the SERPINE1 gene promoter (Homo sapiens)
WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter (Homo sapiens)
SMAD7 binds SERPINE1 gene promoter (Homo sapiens)
as a component of
MITF-M dimer:SERPINE gene [nucleoplasm] (Homo sapiens)
p-BMAL1:p-CLOCK,NPAS2:SERPINE1 gene [nucleoplasm] (Homo sapiens)
SARS-CoV-1 N:p-2S-SMAD3:SP1:EP300:SERPINE1 gene [nucleoplasm] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4:SERPINE1 gene [nucleoplasm] (Homo sapiens)
SMAD7:SERPINE1 gene [nucleoplasm] (Homo sapiens)
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