MITF-M binds SERPINE1 gene

Stable Identifier
R-HSA-9926492
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M binds SERPINE1 gene
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SERPINE1 was identified as a direct transcriptional target of MITF-M-dependent expression in melanoma cells as assessed by ChIP-seq, CUT-and-RUN DNA binding analysis and DNA binding motif analysis (Dilshat et al, 2021; Laurette et al, 2015; Webster et al, 2014). Knockdown of MITF-M by CRISPR or si/sh RNA results in upregulation of SERPINE1 gene expression, consistent with a role for MITF-M as a repressor at this gene (Dilshat et al, 2021).
Literature References
PubMed ID Title Journal Year
25803486 Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

Laurette, P, Strub, T, Koludrovic, D, Keime, C, Le Gras, S, Seberg, H, Van Otterloo, E, Imrichova, H, Siddaway, R, Aerts, S, Cornell, RA, Mengus, G, Davidson, I

Elife 2015
33438577 MITF reprograms the extracellular matrix and focal adhesion in melanoma

Dilshat, R, Fock, V, Kenny, C, Gerritsen, I, Lasseur, RMJ, Travnickova, J, Eichhoff, OM, Cerny, P, Möller, K, Sigurbjornsdottir, S, Kirty, K, Einarsdottir, BO, Cheng, PF, Levesque, M, Cornell, RA, Patton, EE, Larue, L, de Tayrac, M, Magnusdottir, E, Ogmundsdottir, MH, Steingrímsson, E

Elife 2021
24443471 Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition

Webster, DE, Barajas, B, Bussat, RT, Yan, KJ, Neela, PH, Flockhart, RJ, Kovalski, J, Zehnder, A, Khavari, PA

Genome Res 2014
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Authored
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Reviewed
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-11-01)
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