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19S RP lid particle 3 [nucleoplasm]
Stable Identifier
R-HSA-9918363
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PSMD3:PSMD6:SEM1, Rpn3:Rpn7:Sem1, 19S RP LP3
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Independent G1/S DNA Damage Checkpoint (Homo sapiens)
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Homo sapiens)
Proteolytic degradation of ubiquitinated-Cdc25A (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
Circadian clock (Homo sapiens)
Degradation of CRY and PER proteins (Homo sapiens)
Proteolysis of K48polyUb,p-S-CRY1,2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Somitogenesis (Homo sapiens)
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
Participants
components
PSMD3 [nucleoplasm]
(Homo sapiens)
PSMD6 [nucleoplasm]
(Homo sapiens)
SEM1 [nucleoplasm]
(Homo sapiens)
Participates
as a component of
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
Inferred To
19S RP lid particle 3 [nucleoplasm]
(Bos taurus)
19S RP lid particle 3 [nucleoplasm]
(Caenorhabditis elegans)
19S RP lid particle 3 [nucleoplasm]
(Canis familiaris)
19S RP lid particle 3 [nucleoplasm]
(Danio rerio)
19S RP lid particle 3 [nucleoplasm]
(Dictyostelium discoideum)
19S RP lid particle 3 [nucleoplasm]
(Drosophila melanogaster)
19S RP lid particle 3 [nucleoplasm]
(Gallus gallus)
19S RP lid particle 3 [nucleoplasm]
(Mus musculus)
19S RP lid particle 3 [nucleoplasm]
(Rattus norvegicus)
19S RP lid particle 3 [nucleoplasm]
(Saccharomyces cerevisiae)
19S RP lid particle 3 [nucleoplasm]
(Schizosaccharomyces pombe)
19S RP lid particle 3 [nucleoplasm]
(Sus scrofa)
19S RP lid particle 3 [nucleoplasm]
(Xenopus tropicalis)
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