OqxA exports fluoroquinolones

Stable Identifier
R-HSA-9913672
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Escherichia coli
Compartment
plasma membrane, cytosol, periplasmic space
ReviewStatus
3/5
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OqxA exports fluoroquinolones
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OqxA is a transport protein of the Resistance-Nodulation-Cell Division (RND) superfamily which localizes to the plasma membrane. Members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism, utilizing the proton-motive force (reviewed in Nikaido, 2018). The oqxA gene has been found on plasmids of fluoroquinolone-resistant E.coli, and the protein exports a wide variety of antimicrobials (Hansen et al., 2004; Hansen et al., 2007; reviewed in Ruiz et al., 2012; Shariati et al., 2022).
Literature References
PubMed ID Title Journal Year
22831841 Transferable mechanisms of quinolone resistance

Ruiz, J, Pons, MJ, Gomes, C

Int J Antimicrob Agents 2012
17526501 Substrate specificity of the OqxAB multidrug resistance pump in Escherichia coli and selected enteric bacteria

Hansen, LH, Jensen, LB, Sørensen, HI, Sørensen, SJ

J Antimicrob Chemother 2007
15328093 Plasmid-encoded multidrug efflux pump conferring resistance to olaquindox in Escherichia coli

Hansen, LH, Johannesen, E, Burmølle, M, Sørensen, AH, Sørensen, SJ

Antimicrob Agents Chemother 2004
36620240 The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic

Shariati, A, Arshadi, M, Khosrojerdi, MA, Abedinzadeh, M, Ganjalishahi, M, Maleki, A, Heidary, M, Khoshnood, S

Front Public Health 2022
29577985 RND transporters in the living world

Nikaido, H

Res Microbiol 2018
Participants
Input
Output
Participates
as an event of
Catalyst Activity

xenobiotic transmembrane transporter activity of OqxA [plasma membrane]

Physical Entity
OqxA [plasma membrane] (Escherichia coli)
Activity
xenobiotic transmembrane transporter activity (GO:0042910)
Disease
Cross References
Mondo
Authored
Stephan, R  (2024-06-17)
Created
Stephan, R  (2024-06-17)
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