AAC(6′)-Ib acetylates ciprofloxacin

Stable Identifier
R-HSA-9913373
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Escherichia coli
Compartment
cytosol
ReviewStatus
3/5
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AAC(6′)-Ib acetylates ciprofloxacin
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Many E.coli plasmids contain genes coding for AAC(6′)-Ib which acetylates fluoroquinolones like ciprofloxacin at the 4-amino position of the piperazinyl moiety (Robicsek et al., 2006; Vetting et al., 2008; reviewed in Ruiz et al., 2012; Shariati et al., 2022).
Literature References
PubMed ID Title Journal Year
22831841 Transferable mechanisms of quinolone resistance

Ruiz, J, Pons, MJ, Gomes, C

Int J Antimicrob Agents 2012
18710261 Mechanistic and structural analysis of aminoglycoside N-acetyltransferase AAC(6')-Ib and its bifunctional, fluoroquinolone-active AAC(6')-Ib-cr variant

Vetting, MW, Park, CH, Hegde, SS, Jacoby, GA, Hooper, DC, Blanchard, JS

Biochemistry 2008
16369542 Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase

Robicsek, A, Strahilevitz, J, Jacoby, GA, Macielag, M, Abbanat, D, Park, CH, Bush, K, Hooper, DC

Nat Med 2006
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Catalyst Activity

N-acetyltransferase activity of AAC(6')-Ib [cytosol]

Physical Entity
AAC(6')-Ib [cytosol] (Escherichia coli)
Activity
N-acetyltransferase activity (GO:0008080)
Disease
Cross References
Mondo
Authored
Stephan, R  (2024-06-13)
Created
Stephan, R  (2024-06-13)
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