TetA exports tetracyclines

Stable Identifier
R-HSA-9913128
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Escherichia coli
Compartment
plasma membrane, cytosol, periplasmic space
ReviewStatus
3/5
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TetA exports tetracyclines
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A common tetracycline resistance gene in human infections with E. coli are genes coding for the TetA transmembrane transporter of major facilitator type (Schwaiger et al., 2010). TetA proteins export tetracyclines via a proton antiport mechanism (Sapunaric & Levy, 2005). There are at least four homologous tetA genes in the E. coli genome, localized on plasmids.
Literature References
PubMed ID Title Journal Year
16000721 Substitutions in the interdomain loop of the Tn10 TetA efflux transporter alter tetracycline resistance and substrate specificity

Sapunaric, FM, Levy, SB

Microbiology (Reading) 2005
19939589 Resistance gene patterns of tetracycline resistant Escherichia coli of human and porcine origin

Schwaiger, K, Hölzel, C, Bauer, J

Vet Microbiol 2010
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Output
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as an event of
Catalyst Activity

xenobiotic transmembrane transporter activity of TetA homologs [plasma membrane]

Physical Entity
TetA homologs [plasma membrane] (Escherichia coli)
Activity
xenobiotic transmembrane transporter activity (GO:0042910)
Disease
Cross References
Mondo
Authored
Stephan, R  (2024-06-23)
Created
Stephan, R  (2024-06-11)
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