TetB exports tetracyclines

Stable Identifier
R-HSA-9913106
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Escherichia coli
Compartment
plasma membrane, cytosol, periplasmic space
ReviewStatus
3/5
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TetB exports tetracyclines
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In a study of tetracycline resistant E. coli the most common resistance gene in human infections was tetB. The encoded protein is a transmembrane transporter of the major facilitator type (Schwaiger et al., 2010). Homologous proteins export tetracyclines via a proton antiport mechanism (Sapunaric & Levy, 2005).
Literature References
PubMed ID Title Journal Year
16000721 Substitutions in the interdomain loop of the Tn10 TetA efflux transporter alter tetracycline resistance and substrate specificity

Sapunaric, FM, Levy, SB

Microbiology (Reading) 2005
19939589 Resistance gene patterns of tetracycline resistant Escherichia coli of human and porcine origin

Schwaiger, K, Hölzel, C, Bauer, J

Vet Microbiol 2010
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Output
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Catalyst Activity

xenobiotic transmembrane transporter activity of TetB [plasma membrane]

Physical Entity
TetB [plasma membrane] (Escherichia coli)
Activity
xenobiotic transmembrane transporter activity (GO:0042910)
Disease
Cross References
Mondo
Authored
Stephan, R  (2024-06-11)
Created
Stephan, R  (2024-06-11)
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