Reactome | PSMG1 binds PSMG2

PSMG1 binds PSMG2

Stable Identifier

R-HSA-9908051

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

3/5

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Proteasome chaperone proteins PSMG1 (also known as PAC1, ortholog of yeast Pba1) and PSMG2 (also known as PAC2, ortholog of yeast Pba2) form a dimer originally reported in yeast (reviewed in Tomko and Hochstrasser 2013) and subsequently confirmed in human cells (Hirano et al. 2005; Hirano et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16251969	A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes Hirano, Y, Hendil, KB, Yashiroda, H, Iemura, S, Nagane, R, Hioki, Y, Natsume, T, Tanaka, K, Murata, S	Nature	2005
17189198	Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes Hirano, Y, Hayashi, H, Iemura, S, Hendil, KB, Niwa, S, Kishimoto, T, Kasahara, M, Natsume, T, Tanaka, K, Murata, S	Mol Cell	2006