Expression of the DGAT2 gene, encoding Diacylglycerol O-acyltransferase 2, an essential acyltransferase required for synthesis and storage of intracellular triglycerides, is positively regulated in fat tissue by the PPARG:RXRA heterodimer and KMT2C (MLL3)/KMT2D (MLL4) histone methyltransferase complexes. In the adipose tissue of Fgf21 knockout mice, the activity of Pparg is decreased due to SUMOylation, which correlates with a lower expression of Dgat2 gene that can be restored by Fgf21 administration or expression of a SUMOylation-resistant Pparg mutant (Dutchak et al. 2012). Twist1-mediated direct repression of Pparg transcription in mouse white adipocytes correlates with reduced Dgat2 mRNA levels (Sun et al. 2023). Expression of the Dgat2 gene is severely reduced in differentiating mouse brown preadipocytes expressing histone H3.3 K4M mutant or Kmt2c (Mll3) and Kmt2d (Mll4) with deleted SET domains (Jang et al. 2019: RNA-seq, supplementary information).