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DGAT2 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-549188
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Diacylglycerol O-acyltransferase 2
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Homo sapiens)
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Homo sapiens)
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Homo sapiens)
DGAT2 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
DGAT2 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
Glycerophospholipid biosynthesis (Homo sapiens)
Acyl chain remodeling of DAG and TAG (Homo sapiens)
DAG is acylated to TAG by DGAT1/2 (Homo sapiens)
DGAT1/2 [endoplasmic reticulum membrane] (Homo sapiens)
DGAT2 [endoplasmic reticulum membrane] (Homo sapiens)
Triglyceride metabolism (Homo sapiens)
Triglyceride biosynthesis (Homo sapiens)
1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Homo sapiens)
DGAT2 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96PD7 DGAT2
Gene Names
DGAT2, HMFN1045, UNQ738/PRO1433
Chain
chain:1-388
Reference Genes
BioGPS Gene:84649 DGAT2
COSMIC (genes):DGAT2 DGAT2
CTD Gene:84649 DGAT2
dbSNP Gene:84649 DGAT2
ENSEMBL:ENSG00000062282 DGAT2
HGNC:16940 DGAT2
KEGG:hsa:84649 DGAT2
Monarch:84649 DGAT2
NCBI Gene:84649 DGAT2
OMIM:606983 DGAT2
UCSC:Q96PD7 DGAT2
Reference Transcript
RefSeq:NM_001253891.1 DGAT2
RefSeq:NM_032564.4 DGAT2
Other Identifiers
11722641_s_at
11722642_a_at
16729168
224327_PM_s_at
224327_s_at
226064_PM_s_at
226064_s_at
3340666
3340667
3340668
3340669
3340670
3340675
3340676
3340679
3340680
3340682
3340683
3340684
3340685
3340686
3340687
3340688
3340689
3340690
3340691
53200_at
61308_at
7942613
84649
A_14_P100208
A_23_P53198
A_24_P295791
GE61374
GO:0003824
GO:0003846
GO:0004144
GO:0005515
GO:0005737
GO:0005739
GO:0005783
GO:0005789
GO:0005811
GO:0005829
GO:0005975
GO:0006071
GO:0006629
GO:0006640
GO:0006651
GO:0006790
GO:0008374
GO:0016020
GO:0016740
GO:0016746
GO:0019432
GO:0019915
GO:0034383
GO:0035336
GO:0035356
GO:0042572
GO:0042632
GO:0042803
GO:0043226
GO:0043231
GO:0046339
GO:0048471
GO:0048856
GO:0050252
GO:0055086
GO:0055089
GO:0060613
GO:0071400
GO:0097006
GO:1901135
GO:1990578
HMNXSV003042002
Hs.74637.1.A1_3p_s_at
ILMN_1681520
PH_hs_0016405
TC11000812.hg
g13537296_3p_s_at
Participates
as an output of
DGAT2 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
as a member of
DGAT1/2 [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
Dmel\CG1941 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
DGAT2 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
DGAT2 [endoplasmic reticulum membrane]
(Canis familiaris)
DGAT2 [endoplasmic reticulum membrane]
(Gallus gallus)
dga1 [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
dgat2 [endoplasmic reticulum membrane]
(Danio rerio)
dgat2 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
dgat2 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
DGA1 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
Dmel\CG1946 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
LOC110259135 [endoplasmic reticulum membrane]
(Sus scrofa)
dgat-2 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
dgtr-1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Homologues of DGAT2 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Homologues of DGAT2 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Dgat2 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Dgat2 [endoplasmic reticulum membrane]
(Mus musculus)
Dgat2 [endoplasmic reticulum membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_115953.2
,
NP_001240820.1
Guide to Pharmacology - Targets
3211
ENSEMBL
ENSP00000228027
,
ENST00000376262
,
ENSP00000365438
,
ENST00000228027
OpenTargets
ENSG00000062282
ZINC - Substances
DGAT2_HUMAN
ZINC target
Q96PD7
PRO
Q96PD7
IntEnz
2.3.1.20
HPA
ENSG00000062282-DGAT2
Pharos - Targets
Q96PD7
Orphanet
DGAT2
ZINC - Predictions - Purchasable
DGAT2_HUMAN
HMDB Protein
HMDBP04483
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