MITF-M dimer binds DIAPH1 gene

Stable Identifier
R-HSA-9857574
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M dimer binds DIAPH1 gene
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MITF-M binds to cognate binding sites in the promoter of the DIAPH1 gene to activate expression as assessed by ChIP, EMSA and reporter gene assay (Carreira et al, 2006). Through its regulation of DIAPH1 expression, MITF-M impacts both the actin cytoskeleton and cell cycle progression (Carreira et al, 2006; reviewed in Hou and Pavan, 2008; Goding and Arnheiter, 2019). Low levels of MITF-M lead to downregulation of DIAPH1, alterations in F-actin organization leading to a rounded cell morphology, stabilization of the cell cycle inhibitor CDKN1B (p27kip1) and increased invasiveness (Carreira et al, 2006). DIAPH1 positively regulates RAC to promote actin reorganization at the cell periphery, and additionally acts through SKP2 to positively regulate CDKN1B/p27 stability, thus coordinating MITF-dependent processes of proliferation and invasiveness (Carreira et al, 2006; Tsuji et al, 2002; Mammoto et al, 2004; Carrano et al, 1999; Tsvetkov et al, 1999; reviewed in Hou and Pavan, 2008; Goding and Arnheiter, 2019).
Literature References
PubMed ID Title Journal Year
10559916 SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Carrano, AC, Eytan, E, Hershko, A, Pagano, M

Nat Cell Biol 1999
11076759 Signaling and transcriptional regulation in the neural crest-derived melanocyte lineage: interactions between KIT and MITF

Hou, L, Panthier, JJ, Arnheiter, H

Development 2000
17182868 Mitf regulation of Dia1 controls melanoma proliferation and invasiveness

Carreira, S, Goodall, J, Denat, L, Rodriguez, M, Nuciforo, P, Hoek, KS, Testori, A, Larue, L, Goding, CR

Genes Dev 2006
12021256 ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts

Tsuji, T, Ishizaki, T, Okamoto, M, Higashida, C, Kimura, K, Furuyashiki, T, Arakawa, Y, Birge, RB, Nakamoto, T, Hirai, H, Narumiya, S

J Cell Biol 2002
31123060 MITF-the first 25 years

Goding, CR, Arnheiter, H

Genes Dev 2019
15096506 Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition

Mammoto, A, Huang, S, Moore, K, Oh, P, Ingber, DE

J Biol Chem 2004
10375532 p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

Tsvetkov, LM, Yeh, KH, Lee, SJ, Sun, H, Zhang, H

Curr Biol 1999
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Authored
Rothfels, K  (2023-12-21)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-01-07)
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