MITF-M dimer binds the CEACAM1 gene

Stable Identifier
R-HSA-9856062
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M dimer binds the CEACAM1 gene
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MITF-M binds to the promoter of the CEACAM1 gene as assessed by chromatin immunoprecipitation (Strub et al, 2011; Ullrich et al, 2015). MITF-M-dependent expression of CEACAM1 contributes to cell adhesion and invasiveness, particularly in melanoma (Ullrich et al, 2015; reviewed in Goding and Arnheiter, 2019).
Literature References
PubMed ID Title Journal Year
26301891 MITF is a critical regulator of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in malignant melanoma

Ullrich, N, Löffek, S, Horn, S, Ennen, M, Sánchez-Del-Campo, L, Zhao, F, Breitenbuecher, F, Davidson, I, Singer, BB, Schadendorf, D, Goding, CR, Helfrich, I

Pigment Cell Melanoma Res 2015
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Strub, T, Giuliano, S, Ye, T, Bonet, C, Keime, C, Kobi, D, Le Gras, S, Cormont, M, Ballotti, R, Bertolotto, C, Davidson, I

Oncogene 2011
31123060 MITF-the first 25 years

Goding, CR, Arnheiter, H

Genes Dev 2019
Participants
Input
Output
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Authored
Rothfels, K  (2023-12-21)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2023-12-09)
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