NPM1-ALK-stimulated PRF1 gene expression

Stable Identifier
R-HSA-9851131
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytolytic granule lumen
ReviewStatus
5/5
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NPM1-ALK-stimulated PRF1 gene expression
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Performin 1 (PFR1) is a pore-forming protein that plays a role in granzyme (GZMB)-stimulated programmed cell death in response to infection or disease (reviewed in Arias et al, 2017; Tibbs and Cao, 2022). Expression of PFR1 is upregulated in ALCL cells in a manner that is dependent on NPM1-ALK (Pearson et al, 2011).
Literature References
PubMed ID Title Journal Year
35326588 Emerging Canonical and Non-Canonical Roles of Granzyme B in Health and Disease

Tibbs, E, Cao, X

Cancers (Basel) 2022
21326808 NPM-ALK and the JunB transcription factor regulate the expression of cytotoxic molecules in ALK-positive, anaplastic large cell lymphoma

Ingham, RJ, Bacani, JT, Lai, R, Pearson, JD, Lee, JK

Int J Clin Exp Pathol 2011
28718416 The Untold Story of Granzymes in Oncoimmunology: Novel Opportunities with Old Acquaintances

Ferrandez, A, Santiago, L, Pardo, J, Granville, DJ, Arias, M, Martínez-Lostao, L

Trends Cancer 2017
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [nucleoplasm] (Homo sapiens)
Disease
Authored
Rothfels, K  (2023-10-14)
Reviewed
Turner, S  (2023-11-08)
Created
Rothfels, K  (2023-10-12)
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