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PRF1 [cytolytic granule lumen]
Stable Identifier
R-HSA-9850839
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytolytic granule lumen
Synonyms
Perforin-1, PERF_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
NPM1-ALK-stimulated PRF1 gene expression (Homo sapiens)
PRF1 [cytolytic granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14222 PRF1
Gene Names
PRF1, PFP
Chain
signal peptide:1-21, chain:22-555
Reference Genes
BioGPS Gene:5551 PRF1
COSMIC (genes):PRF1 PRF1
CTD Gene:5551 PRF1
dbSNP Gene:5551 PRF1
ENSEMBL:ENSG00000180644 PRF1
ENSEMBL_homo_sapiens_GENE:ENSG00000180644.8 PRF1
HGNC:9360 PRF1
KEGG Gene (Homo sapiens):5551 PRF1
Monarch:5551 PRF1
NCBI Gene:5551 PRF1
OMIM:170280 PRF1
UCSC:P14222 PRF1
Reference Transcript
RefSeq:NM_005041.4 PRF1
RefSeq:NM_001083116.1 PRF1
Other Identifiers
11729649_at
11747295_a_at
1553681_3p_a_at
1553681_PM_a_at
1553681_a_at
16715170
214617_PM_at
214617_at
32904_at
3293441
3293442
3293443
3293444
3293445
3293446
3293447
3293448
3293449
3293451
5551
7934161
A_23_P1473
GE566269
GO:0001771
GO:0001772
GO:0001909
GO:0001913
GO:0002357
GO:0002376
GO:0002418
GO:0005215
GO:0005509
GO:0005515
GO:0005576
GO:0005764
GO:0005768
GO:0005773
GO:0005829
GO:0005886
GO:0006915
GO:0006968
GO:0009306
GO:0012501
GO:0016020
GO:0017038
GO:0022829
GO:0023052
GO:0031410
GO:0031640
GO:0031904
GO:0042802
GO:0043226
GO:0044194
GO:0046872
GO:0051260
GO:0051607
GO:0051712
GO:0055085
GO:0065003
GO:0071806
GO:0098542
GO:0140507
GO:0140911
HMNXSV003024210
Hs.2200.0.S2_3p_at
Hs2.2200.1.S1_3p_at
Hs2.2200.1.S1_3p_s_at
ILMN_1740633
M31951_at
PH_hs_0000291
TC10001366.hg
Participates
as an output of
NPM1-ALK-stimulated PRF1 gene expression (Homo sapiens)
Cross References
RefSeq
NP_001076585.1
,
NP_005032.2
Guide to Pharmacology - Targets
3100
OpenTargets
ENSG00000180644
ZINC - Substances
PERF_HUMAN
GeneCards
P14222
HPA
ENSG00000180644-PRF1
ZINC target
P14222
Ensembl
ENST00000441259
,
ENSG00000180644
,
ENST00000373209
,
ENSP00000398568
,
ENSP00000362305
PRO
P14222
Pharos - Targets
P14222
ZINC - Predictions - Purchasable
PERF_HUMAN
HMDB Protein
HMDBP02300
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.718
6
UniProt:P14222 PRF1
1
PRF1 [cytolytic granule lumen]
(R-HSA-9850839)
0.626
3
UniProt:P0DPK4 NOTCH2NLC
1
NOTCH2NLC [extracellular region]
(R-HSA-9908932)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
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