p-Y705, S727 STAT3 dimer binds ICOS promoter

Stable Identifier
R-HSA-9851106
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p-Y705, S727 STAT3 dimer binds ICOS promoter
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STAT3 binds to a region of the ICOS promoter downstream of NPM-ALK as assessed by electrophoretic mobility shift assay and chromatin immunoprecipitation. Although the phosphorylation status of STAT3 was not directly examined in the context of the ICOS promoter, STAT3 is a known NPM-ALK target and the stimulation of ICOS expression is dependent on NPM-ALK kinase activity (Zhang et al, 2011; reviewed in Chiarle et al, 2008; Ducray et al, 2019). STAT3 also contributes to ICOS expression through the downregulation of miR-219, a negative regulator of ICOS (Zhang et al, 2011).
Literature References
PubMed ID Title Journal Year
31366041 The Transcriptional Roles of ALK Fusion Proteins in Tumorigenesis

Ducray, SP, Natarajan, K, Garland, GD, Turner, SD, Egger, G

Cancers (Basel) 2019
18097461 The anaplastic lymphoma kinase in the pathogenesis of cancer

Chiarle, R, Voena, C, Ambrogio, C, Piva, R, Inghirami, G

Nat. Rev. Cancer 2008
21765024 Oncogenic tyrosine kinase NPM-ALK induces expression of the growth-promoting receptor ICOS

Zhang, Q, Wang, H, Kantekure, K, Paterson, JC, Liu, X, Schaffer, A, Paulos, C, Milone, MC, Odum, N, Turner, S, Marafioti, T, Wasik, MA

Blood 2011
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
anaplastic large cell lymphoma DOID:0050744
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2023-10-14)
Reviewed
Turner, S  (2023-11-08)
Created
Rothfels, K  (2023-10-12)
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