CLIP1-LTK fusion binds PI3K to activate AKT

Stable Identifier
R-HSA-9845032
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
3/5
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Activated CLIP1-LTK promotes phosphorylation of AKT at serine 473 as assessed by Western blot (Izumi et al, 2021), although recruitment of PI3K to the activated receptor has not been directly demonstrated.
Literature References
PubMed ID Title Journal Year
34819663 The CLIP1-LTK fusion is an oncogenic driverĀ in non-small-cell lung cancer

Ikeda, T, Nakachi, I, Watanabe, K, Kodani, M, Hayashi, K, Sakakibara-Konishi, J, Shibata, Y, Nishino, K, Izumi, H, Okamoto, I, Kirita, K, Goto, K, Nosaki, K, Yoh, K, Niho, S, Ishii, G, Matsumoto, S, Kuyama, S, Sakai, T, Liu, J, Furuya, N, Sugiyama, E, Nakai, T, Tanaka, K, Kumagai, S, Yamasaki, A, Daga, H, Zenke, Y, Taima, K, Ebi, N, Hayashida, T, Kato, T, Fukuhara, T, Mori, S, Kobayashi, SS, Udagawa, H, Ohtsu, A, Nakamura, A

Nature 2021
Participants
Participates
Disease
Name Identifier Synonyms
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Created
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