Smad1:Smad4 trimer binds Znf423

Stable Identifier
R-MMU-9844497
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Smad1:Smad4 trimer binds Znf423
In the mouse adipose lineages, bone morphogenic protein Bmp7, known as the brown fat determination factor, stimulates formation of an active SMAD heterotrimer composed of two molecules of phosphorylated Smad1 and one molecule of Smad4 that binds to Znf423 transcription factor. Binding of Znf423 to the Bmp7-induced complex of Smad1 and Smad4 interferes with association of Znf423 with the Ebf2 transcription factor (Shao et al. 2016).
Literature References
PubMed ID Title Journal Year
27238639 Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program

Shao, M, Ishibashi, J, Kusminski, CM, Wang, QA, Hepler, C, Vishvanath, L, MacPherson, KA, Spurgin, SB, Sun, K, Holland, WL, Seale, P, Gupta, RK

Cell Metab 2016
Participants
Input
Output
This event is regulated
Positively by
Regulator
Bmp7 dimer [extracellular region] (Mus musculus)
Active Unit
Bmp7 dimer [extracellular region]
Orthologous Events
SMAD1:SMAD4 trimer binds ZNF423 (Homo sapiens)
Authored
Orlic-Milacic, M  (2023-09-25)
Reviewed
Chun, TH  (2023-12-01)
Created
Orlic-Milacic, M  (2023-09-18)
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