CLIP1-LTK fusion autophosphorylates

Stable Identifier
R-HSA-9842667
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
3/5
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After dimerization, CLIP1(1-1083)-LTK(488-864) autophosphorylates (Izumi et al, 2021).
Literature References
PubMed ID Title Journal Year
34819663 The CLIP1-LTK fusion is an oncogenic driverĀ in non-small-cell lung cancer

Ikeda, T, Nakachi, I, Watanabe, K, Kodani, M, Hayashi, K, Sakakibara-Konishi, J, Shibata, Y, Nishino, K, Izumi, H, Okamoto, I, Kirita, K, Goto, K, Nosaki, K, Yoh, K, Niho, S, Ishii, G, Matsumoto, S, Kuyama, S, Sakai, T, Liu, J, Furuya, N, Sugiyama, E, Nakai, T, Tanaka, K, Kumagai, S, Yamasaki, A, Daga, H, Zenke, Y, Taima, K, Ebi, N, Hayashida, T, Kato, T, Fukuhara, T, Mori, S, Kobayashi, SS, Udagawa, H, Ohtsu, A, Nakamura, A

Nature 2021
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of CLIP1(1-1083)-LTK(488-864) fusion dimer [plasma membrane]

Disease
Name Identifier Synonyms
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Created
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