Dengue Virus Infection

Stable Identifier
R-HSA-9839923
DOI
10.3180/R-HSA-9839923.1
Type
Pathway
Species
Homo sapiens
Related Species
Dengue virus type 2
ReviewStatus
5/5
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Dengue Virus Infection
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Dengue is a mosquito borne viral infection caused by dengue virus (DENV), a member of the Flaviviridae family, genus Flavivirus (reviewed in Neufeldt et al. 2018). Dengue is the most common arthropod borne viral infection in the world (reviewed in Rodenhuis-Zybert et al. 2010). Infection with DENV can proceed asymptomatically, result in a self limited dengue fever, or cause a more severe illness in the form of dengue hemorrhagic fever and dengue shock syndrome (DHF, DSS; reviewed in Rodenhuis-Zybert et al., 2010). Four distinct serotypes of DENV exist (DENV1-4), and acquired immunity is serotype-specific (reviewed in Rodenhuis-Zybert et al., 2010). Secondary infection with a heterologous serotype or primary infection in infants born to dengue-immune mothers are risk factors for developing dengue hemorrhagic fever and dengue shock syndrome, due to antibody-enhanced infectivity (reviewed in Rodenhuis-Zybert et al., 2010).

Like other Flaviviridae, DENV is an enveloped, positive-sense RNA (+ssRNA) virus (reviewed in Rodenhuis-Zybert et al., 2010). Mature dengue virions contain genomic +ssRNA and three structural proteins, C, M, and E (reviewed in Rodenhuis-Zybert et al., 2010). Protein C is the capsid protein which encapsulates genomic +ssRNA, forming the ribonucleocapsid (reviewed in Rodenhuis-Zybert et al., 2010). Proteins M and E, 180 copies of each, are anchored in the host cell-derived viral envelope (reviewed in Rodenhuis-Zybert et al., 2010).

As DENV 2 serotype is the most prevalent (Guo et al., 2017), and its strain Dengue virus 2 Thailand/16681/84 is the most frequently used in molecular studies (tied with strain NGC; based on Reactome-conducted analysis of published literature), reference proteins and RNA molecules specific to this strain were used to annotate events in this pathway. In cases where no direct experimental evidence pertaining to Dengue virus 2 Thailand/16681/84 strain was available, viral life cycle events were manually inferred from related dengue strains, as indicated.
Literature References
PubMed ID Title Journal Year
20372965 Dengue virus life cycle: viral and host factors modulating infectivity

Rodenhuis-Zybert, IA, Wilschut, J, Smit, JM

Cell Mol Life Sci 2010
28748176 Global Epidemiology of Dengue Outbreaks in 1990-2015: A Systematic Review and Meta-Analysis

Guo, C, Zhou, Z, Wen, Z, Liu, Y, Zeng, C, Xiao, D, Ou, M, Han, Y, Huang, S, Liu, D, Ye, X, Zou, X, Wu, J, Wang, H, Zeng, EY, Jing, C, Yang, G

Front Cell Infect Microbiol 2017
Participants
Events
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as an event of
Event Information
Go Biological Process
biological process involved in symbiotic interaction (0044403)
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-10-07)
Orlic-Milacic, M  (2024-08-15)
Reviewed
Mansur, DS  (2025-09-18)
Roque Ascenção, F  (2025-10-29)
Created
Stephan, R  (2023-07-11)
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