Reactome | TGFBR3 degradation

TGFBR3 degradation

Stable Identifier

R-HSA-9839401

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

3/5

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Type III TGF β receptor (TGFBR3) binds to GIPC1 at a Class I PDZ binding motif in the cytoplasmic domain of the TGFBR3 and prevents its degradation thus stabilizing the receptor complex at plasma membrane (Blobe et al.,2001)

Literature References

PubMed ID	Title	Journal	Year
11546783	A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC Lodish, HF, Blobe, GC, How, T, Liu, X, Fang, SJ	J Biol Chem	2001