Expression of GREM1 in metanephric mesenchyme

Stable Identifier
R-HSA-9831017
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
3/5
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Expression of GREM1 in metanephric mesenchyme
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Gremlin 1 (GREM1), a secreted BMP antagonist, is expressed in the metanephric mesenchyme (inferred from the mouse homolog). Expression of GREM1 in the metanephric mesenchyme is dependent on SIX1 (inferred from mouse homologs). In mice, absence of Grem1 causes disrupted ureter growth and branching (Michos et al. 2004) due to excessive Bmp4 signaling via phospho-Smad proteins (Michos et al. 2007).
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
SIX1 [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Grem1 in metanephric mesenchyme (Mus musculus)
Authored
May, B  (2023-03-17)
Created
May, B  (2023-03-17)
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