p-S742 TBX3 binds ID1 promoter

Stable Identifier
R-HSA-9825776
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p-S742 TBX3 binds ID1 promoter
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AKT3-phosphorylated TBX3 binds to the promoter of ID1 to activate expression, as assessed by electrophoretic mobility shift assays, chromatin immunoprecipitation and reporter gene assays (Peres et al, 2021). ID1 is a member of the ID1 - 4 family of helix-loop-helix proteins that lack the DNA binding region and consequently act as dominant negative inhibitors of other HLH-containing proteins upon heterodimerization (Massari and Murre, 2000; reviewed in Perk et al, 2005; Ling et al, 2014). In osteoclast cells, ID1 has been shown to bind to MITF, and MITF has been shown to directly activate CDH1 expression (Lee et al, 2006; Mansky et al, 2002; Dilshat et al,2021). In melanoma cells, TBX3 also upregulates ID1 expression which prevents MITF from binding and activating the CDH1 promoter (Peres et al, 2021).
Literature References
PubMed ID Title Journal Year
25248477 Id proteins: small molecules, mighty regulators

Ling, F, Kang, B, Sun, XH

Curr. Top. Dev. Biol. 2014
10611221 Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms

Murre, C, Massari, ME

Mol. Cell. Biol. 2000
16034366 Id family of helix-loop-helix proteins in cancer

Benezra, R, Iavarone, A, Perk, J

Nat. Rev. Cancer 2005
11818451 The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts

Purdom, GH, Luchin, A, Marfatia, K, Ostrowski, MC, Hume, DA, Mansky, KC

J Leukoc Biol 2002
16322470 Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation

Kim, JH, Lee, J, Lee, SY, Kim, N, Choi, Y, Kim, K, Kook, H, Choi, HK, Lee, SH, Jin, HM, Yokota, Y, Kim, KK

Blood 2006
34003523 Epigenetic regulation during melanocyte development and homeostasis

Dilshat, R, Steingrímsson, E, Vu, HN

Exp Dermatol 2021
33744299 TBX3 Promotes Melanoma Migration by Transcriptional Activation of ID1, which Prevents Activation of E-Cadherin by MITF

Peres, J, Galibert, MD, Prince, S, Popovic, A, Goding, CR, Damerell, V, Chauhan, J, Desprez, PY

J Invest Dermatol 2021
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Authored
Rothfels, K  (2023-01-26)
Reviewed
de la Serna, IL  (2024-05-21)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2023-01-26)
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