p-S133-CREB1 binds MITF promoter

Stable Identifier
R-HSA-9824653
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-S133-CREB1 binds MITF promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Alpha-melanocyte-stimulating hormone (alpha MSH) stimulates transcription of MITF in developing melanocytes and in melanoma cells by promoting the cAMP-dependent phosphorylation of CREB1 and serine 133. Phosphorylated CREB1 binds to a CRE element in the MITF-M promoter as assessed by electrophoretic mobility shift assay and stimulates transcription of MITF (Bertolotto et al,1998; Price et al, 1998). CREB-stimulated transcriptional activation of the MITF-M promoter is also dependent on the upstream SOX10 binding site (Huber et al, 2003).
Literature References
PubMed ID Title Journal Year
9830058 alpha-Melanocyte-stimulating hormone signaling regulates expression of microphthalmia, a gene deficient in Waardenburg syndrome

Price, ER, Horstmann, MA, Wells, AG, Weilbaecher, KN, Takemoto, CM, Landis, MW, Fisher, DE

J Biol Chem 1998
9700169 Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes

Bertolotto, C, Abbe, P, Hemesath, TJ, Bille, K, Fisher, DE, Ortonne, JP, Ballotti, R

J Cell Biol 1998
12944398 A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes

Huber, WE, Price, ER, Widlund, HR, Du, J, Davis, IJ, Wegner, M, Fisher, DE

J Biol Chem 2003
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
Authored
Rothfels, K  (2023-01-26)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2023-01-21)
Cite Us!