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METTL23 and STGP4 (GSE) bind H3.3 dimethylarginine-17 (H3K17me2a)
Stable Identifier
R-HSA-9822597
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Maternal to zygotic transition (MZT) (Homo sapiens)
Chromatin modifications during the maternal to zygotic transition (MZT) (Homo sapiens)
METTL23 and STGP4 (GSE) bind H3.3 dimethylarginine-17 (H3K17me2a) (Homo sapiens)
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METTL23 binds both chromatin (probably via dimethylarginine-17 of histone H3.3) and STGP4 (GSE) (inferred from mouse homologs). METTL23 and STGP4 are required for localizing TET3 to the pronuclei of the zygote (inferred from mouse zygotes).
Participants
Input
Chromatin with H3.3 dimethylarginine-17, H2AX, and 5mC [nucleoplasm]
(Homo sapiens)
METTL23 [nucleoplasm]
(Homo sapiens)
STPG4 [nucleoplasm]
(Homo sapiens)
Output
STGP4:METTL23:Chromatin with H3.3 dimethylarginine-17, H2A.x, and 5-mC [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Chromatin modifications during the maternal to zygotic transition (MZT) (Homo sapiens)
Inferred From
Mettl23 and Stgp4 (Gse) bind chromatin with H3.3 dimethylarginine-17 (Mus musculus)
Authored
May, B (2022-12-26)
Reviewed
Xie, W (2023-08-08)
Created
May, B (2022-12-26)
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