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METTL23 [nucleoplasm]
Stable Identifier
R-HSA-9822595
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
fullName evidence="8"Histone-arginine methyltransferase METTL23 ecNumber evidence="1"2.1.1.319/ecNumber, MET23_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Maternal to zygotic transition (MZT) (Homo sapiens)
Chromatin modifications during the maternal to zygotic transition (MZT) (Homo sapiens)
METTL23 and STGP4 (GSE) bind H3.3 dimethylarginine-17 (H3K17me2a) (Homo sapiens)
METTL23 [nucleoplasm] (Homo sapiens)
STGP4:METTL23:Chromatin with H3.3 dimethylarginine-17, H2A.x, and 5-mC [nucleoplasm] (Homo sapiens)
METTL23 [nucleoplasm] (Homo sapiens)
TET3 binds chromatin with H3K17me2a and 5-mC:METTL23:STGP4 (Homo sapiens)
STGP4:METTL23:Chromatin with H3.3 dimethylarginine-17, H2A.x, and 5-mC [nucleoplasm] (Homo sapiens)
METTL23 [nucleoplasm] (Homo sapiens)
TET3:STGP4:METTL23:Chromatin with H3.3 dimethylarginine-17, H2A.x, and 5-mC [nucleoplasm] (Homo sapiens)
METTL23 [nucleoplasm] (Homo sapiens)
TET3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine in chromatin containing histone H3.3 (Homo sapiens)
TET3:STGP4:METTL23:Chromatin with H3.3 dimethylarginine-17, H2A.x, and 5-mC [nucleoplasm] (Homo sapiens)
METTL23 [nucleoplasm] (Homo sapiens)
TET3:STGP4:METTL23:Chromatin with H3.3 dimethylarginine-4 and 5-hmC [nucleoplasm] (Homo sapiens)
METTL23 [nucleoplasm] (Homo sapiens)
Replacement of protamines by nucleosomes in the male pronucleus (Homo sapiens)
METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein) (Homo sapiens)
METTL23 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86XA0 METTL23
Gene Names
METTL23, C17orf95
Chain
chain:1-190
Reference Genes
BioGPS Gene:124512 METTL23
COSMIC (genes):METTL23 METTL23
CTD Gene:124512 METTL23
dbSNP Gene:124512 METTL23
ENSEMBL:ENSG00000181038 METTL23
HGNC:26988 METTL23
KEGG:hsa:124512 METTL23
Monarch:124512 METTL23
NCBI Gene:124512 METTL23
OMIM:615262 METTL23
UCSC:Q86XA0 METTL23
Reference Transcript
RefSeq:NM_001302704.1 METTL23
RefSeq:NM_001206984.2 METTL23
RefSeq:XM_006721674.3 METTL23
RefSeq:NM_001080510.4 METTL23
RefSeq:NM_001302703.1 METTL23
RefSeq:NM_001302705.1 METTL23
RefSeq:NM_001206986.2 METTL23
RefSeq:NM_001206985.2 METTL23
RefSeq:NM_001206983.2 METTL23
RefSeq:XM_006721680.2 METTL23
RefSeq:NM_001206987.2 METTL23
Other Identifiers
11722729_a_at
124512
16838107
225808_PM_at
225808_at
3735601
3735603
3735604
3735605
3735606
3735607
3735608
3735609
3735612
3735613
3735614
3735615
3735616
3735617
3735618
3735619
3735620
3735621
46263_at
8010086
A_21_P0000717
A_23_P416477
A_24_P921477
GO:0001939
GO:0001940
GO:0003824
GO:0005515
GO:0005634
GO:0005737
GO:0006325
GO:0006355
GO:0008168
GO:0016279
GO:0016740
GO:0031072
GO:0032259
GO:0032991
GO:0035242
GO:0035642
GO:0043226
GO:0044725
GO:0044727
GO:0045944
GO:0050877
GO:0050890
GO:0140096
GO:0140297
HMNXSV003001216
Hs.74655.0.A1_3p_at
ILMN_1688727
ILMN_1764323
ILMN_2280731
ILMN_2382724
PH_hs_0031311
TC17000879.hg
TC17002377.hg
Participates
as a component of
TET3:STGP4:METTL23:Chromatin with H3.3 dimethylarginine-4 and 5-hmC [nucleoplasm] (Homo sapiens)
TET3:STGP4:METTL23:Chromatin with H3.3 dimethylarginine-17, H2A.x, and 5-mC [nucleoplasm] (Homo sapiens)
STGP4:METTL23:Chromatin with H3.3 dimethylarginine-17, H2A.x, and 5-mC [nucleoplasm] (Homo sapiens)
as an input of
METTL23 and STGP4 (GSE) bind H3.3 dimethylarginine-17 (H3K17me2a) (Homo sapiens)
Cross References
ENSEMBL
ENSG00000181038
,
ENSP00000341543
,
ENST00000615984
,
ENSP00000465890
,
ENSP00000465430
,
ENSP00000466203
,
ENST00000590964
,
ENST00000586752
,
ENST00000588822
,
ENST00000341249
,
ENSP00000482599
OpenTargets
ENSG00000181038
GeneCards
METTL23
HPA
ENSG00000181038-METTL23
PRO
Q86XA0
Pharos - Targets
Q86XA0
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