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PABPN1 binds oligouridylated mRNA
Stable Identifier
R-HSA-9820887
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Maternal to zygotic transition (MZT) (Homo sapiens)
Z-decay: degradation of maternal mRNAs by zygotically expressed factors (Homo sapiens)
PABPN1 binds oligouridylated mRNA (Homo sapiens)
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PABPN1 is expressed during zygotic genome activation, binds terminally uridylated maternal mRNAs, and recruits the 3'-5' exoribonuclease DIS3L2 to degrade the mRNA (inferred from mouse homologs).
Participants
Input
PABPN1 [cytosol]
(Homo sapiens)
Uridylated partially Deadenylated mRNA Complex [cytosol]
(Homo sapiens)
Output
PABPN1:uridylated partially deadenylated mRNA complex [cytosol]
(Homo sapiens)
Participates
as an event of
Z-decay: degradation of maternal mRNAs by zygotically expressed factors (Homo sapiens)
Inferred From
Pabpn1 binds oligouridylated mRNA (Mus musculus)
Authored
May, B (2022-11-20)
Reviewed
Xie, W (2023-08-08)
Created
May, B (2022-11-21)
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