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Pabpn1 binds oligouridylated mRNA
Stable Identifier
R-MMU-9820880
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
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Level 2
Level 3
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Pabpn1 is expressed during zygotic genome activation, binds terminally uridylated maternal mRNAs, and recruits the 3'-5' exoribonuclease Dis3l2 to degrade the mRNA (Zhao et al. 2022).
Literature References
PubMed ID
Title
Journal
Year
34904664
Nuclear poly(A) binding protein 1 (PABPN1) mediates zygotic genome activation-dependent maternal mRNA clearance during mouse early embryonic development
Zhao, LW
,
Fan, HY
,
Zhu, YZ
,
Shen, L
,
Pi, SB
,
Wu, YW
Nucleic Acids Res
2022
Participants
Input
Pabpn1 [cytosol]
(Mus musculus)
Uridylated partially deadenylated mRNA complex [cytosol]
(Mus musculus)
Output
Pabpn1:uridylated partially deadenylated mRNA complex [cytosol]
(Mus musculus)
Orthologous Events
PABPN1 binds oligouridylated mRNA (Homo sapiens)
Authored
May, B (2022-11-20)
Reviewed
Xie, W (2023-08-08)
Created
May, B (2022-11-21)
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