Reactome | Displacement of C2a/Bb by CR1

Displacement of C2a/Bb by CR1

Stable Identifier

R-HSA-977629

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Complement Receptor 1 (CR1) displaces the activated enzyme components Bb and C2a from the conventional and alternative C3 convertases C4bC2a and C3bBb, respectivley.

Literature References

PubMed ID	Title	Journal	Year
10531307	Decay accelerating activity of complement receptor type 1 (CD35). Two active sites are required for dissociating C5 convertases Krych-Goldberg, M, Hauhart, RE, Subramanian, VB, Yurcisin BM, 2nd, Crimmins, DL, Hourcade, DE, Atkinson, JP	J Biol Chem	1999
11694537	Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb Hourcade, DE, Mitchell, L, Kuttner-Kondo, LA, Atkinson, JP, Medof, ME	J Biol Chem	2002
293688	Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane Fearon, DT	Proc Natl Acad Sci U S A	1979