Displacement of C2a/Bb by CR1

Stable Identifier
R-HSA-977629
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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Displacement of C2a/Bb by CR1
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Complement Receptor 1 (CR1) displaces the activated enzyme components Bb and C2a from the conventional and alternative C3 convertases C4bC2a and C3bBb, respectivley.
Literature References
PubMed ID Title Journal Year
10531307 Decay accelerating activity of complement receptor type 1 (CD35). Two active sites are required for dissociating C5 convertases

Atkinson, JP, Hauhart, RE, Subramanian, VB, Krych-Goldberg, M, Crimmins, DL, Hourcade, DE, Yurcisin BM, 2nd

J Biol Chem 1999
11694537 Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb

Atkinson, JP, Kuttner-Kondo, LA, Medof, ME, Mitchell, L, Hourcade, DE

J Biol Chem 2002
293688 Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane

Fearon, DT

Proc Natl Acad Sci U S A 1979
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Orthologous Events
CREG (CR1L) causes dissociation of C3 convertases (Gallus gallus)
Displacement of C2a/Bb by CR1 (Canis familiaris)
Displacement of C2a/Bb by CR1 (Gallus gallus)
Displacement of C2a/Bb by CR1 (Sus scrofa)
Authored
Jupe, S  (2010-10-26)
Reviewed
Fraczek, LA  (2012-02-13)
Bradley, DT  (2012-02-13)
Created
Jupe, S  (2010-10-20)
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