Displacement of C2a/Bb by CR1

Stable Identifier
R-HSA-977629
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Complement Receptor 1 (CR1) displaces the activated enzyme components Bb and C2a from the conventional and alternative C3 convertases C4bC2a and C3bBb, respectivley.

Literature References
PubMed ID Title Journal Year
11694537 Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb

Hourcade, DE, Mitchell, L, Kuttner-Kondo, LA, Atkinson, JP, Medof, ME

J Biol Chem 2002
10531307 Decay accelerating activity of complement receptor type 1 (CD35). Two active sites are required for dissociating C5 convertases

Krych-Goldberg, M, Hauhart, RE, Subramanian, VB, Yurcisin BM, 2nd, Crimmins, DL, Hourcade, DE, Atkinson, JP

J Biol Chem 1999
293688 Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane

Fearon, DT

Proc Natl Acad Sci U S A 1979
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