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CFB(260-764) [extracellular region]
Stable Identifier
R-HSA-182453
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Complement Factor Bb
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Activation of C3 and C5 (Homo sapiens)
Cleavage of C3 by C3 convertases (Homo sapiens)
C3 convertases [plasma membrane] (Homo sapiens)
C3(H2O):Bb [extracellular region] (Homo sapiens)
CFB(260-764) [extracellular region] (Homo sapiens)
Initial triggering of complement (Homo sapiens)
Alternative complement activation (Homo sapiens)
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Homo sapiens)
C3(H2O):Bb [extracellular region] (Homo sapiens)
CFB(260-764) [extracellular region] (Homo sapiens)
CFB(260-764) [extracellular region] (Homo sapiens)
Factor D cleaves C3(H2O)-bound Factor B (Homo sapiens)
C3(H2O):Bb [extracellular region] (Homo sapiens)
CFB(260-764) [extracellular region] (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
C3 convertases spontaneously dissociate (Homo sapiens)
C3 convertases [plasma membrane] (Homo sapiens)
C3(H2O):Bb [extracellular region] (Homo sapiens)
CFB(260-764) [extracellular region] (Homo sapiens)
CFB(260-764) [extracellular region] (Homo sapiens)
CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Homo sapiens)
CFB(260-764) [extracellular region] (Homo sapiens)
Displacement of C2a/Bb by CR1 (Homo sapiens)
CFB(260-764) [extracellular region] (Homo sapiens)
Factor H displaces Bb (Homo sapiens)
CFB(260-764) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00751 CFB
Gene Names
CFB, BF, BFD
Chain
signal peptide:1-25, chain:26-764, chain:26-259, chain:260-764
Reference Genes
BioGPS Gene:629 CFB
COSMIC (genes):CFB CFB
CTD Gene:629 CFB
dbSNP Gene:629 CFB
ENSEMBL:ENSG00000239754 CFB
ENSEMBL:ENSG00000241253 CFB
ENSEMBL:ENSG00000241534 CFB
ENSEMBL:ENSG00000242335 CFB
ENSEMBL:ENSG00000243570 CFB
ENSEMBL:ENSG00000243649 CFB
ENSEMBL_homo_sapiens_GENE:ENSG00000239754.9 CFB
ENSEMBL_homo_sapiens_GENE:ENSG00000241253.8 CFB
ENSEMBL_homo_sapiens_GENE:ENSG00000241534.9 CFB
ENSEMBL_homo_sapiens_GENE:ENSG00000242335.8 CFB
ENSEMBL_homo_sapiens_GENE:ENSG00000243570.9 CFB
ENSEMBL_homo_sapiens_GENE:ENSG00000243649.10 CFB
HGNC:1037 CFB
KEGG Gene (Homo sapiens):629 CFB
Monarch:629 CFB
NCBI Gene:629 CFB
OMIM:138470 CFB
UCSC:P00751 CFB
Reference Transcript
RefSeq:NM_001710.5 CFB
Other Identifiers
11733725_a_at
11744331_a_at
11749355_a_at
17006949
202357_3p_s_at
202357_PM_s_at
202357_s_at
2902837
2902846
2902848
2902849
2902852
2902853
2902854
2902855
2902856
2902858
2902859
2902861
2902864
2902867
2902868
2902870
2902871
2902872
2902875
2902876
2902877
2902880
2902881
2902882
2902883
35822_at
629
8118345
8178115
8179351
A_14_P116860
A_23_P156687
A_32_P162183
GE62019
GO:0001848
GO:0002376
GO:0003824
GO:0004252
GO:0005515
GO:0005576
GO:0005601
GO:0005615
GO:0005886
GO:0006508
GO:0006956
GO:0006957
GO:0008233
GO:0008236
GO:0009617
GO:0016787
GO:0043226
GO:0045087
GO:0070062
GO:0072562
GO:0098542
GO:0140096
HMNXSV003050772
ILMN_1774287
L15702_at
PH_hs_0004112
TC06004077.hg
TC6_cox_hap2000245.hg
TC6_dbb_hap3000222.hg
TC6_mann_hap4000196.hg
TC6_mcf_hap5000213.hg
TC6_qbl_hap6000225.hg
TC6_ssto_hap7000199.hg
g4502396_3p_at
g4502396_3p_s_at
g4502396_3p_x_at
p33713
Participates
as an output of
C3 convertases spontaneously dissociate (Homo sapiens)
CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Homo sapiens)
Factor H displaces Bb (Homo sapiens)
Displacement of C2a/Bb by CR1 (Homo sapiens)
as a component of
C3(H2O):Bb [extracellular region] (Homo sapiens)
Other forms of this molecule
CFB(26-259) [extracellular region]
CFB(26-764) [extracellular region]
CFB(260-764) [plasma membrane]
Inferred To
cfb [extracellular region]
(Xenopus tropicalis)
Cfb [extracellular region]
(Mus musculus)
cfbl [extracellular region]
(Danio rerio)
CFB [extracellular region]
(Bos taurus)
CFB [extracellular region]
(Canis familiaris)
CFB [extracellular region]
(Sus scrofa)
bfb [extracellular region]
(Danio rerio)
Homologues of CFB(260-764) [extracellular region]
(Danio rerio)
CFB(260-764) [extracellular region]
(Gallus gallus)
Cross References
RefSeq
NP_001701.2
Guide to Pharmacology - Targets
2339
OpenTargets
ENSG00000243649
ZINC - Substances
CFAB_HUMAN
ZINC target
P00751
PRO
P00751
PDB
6T8U
,
7JTN
,
6T8V
,
7NOZ
,
6RUV
,
6T8W
,
3HRZ
,
2XWJ
,
7JTQ
,
6RUR
,
3HS0
,
2OK5
,
2XWB
,
1RS0
,
1DLE
,
6QSX
,
1Q0P
,
6RAV
,
8EOK
,
8ENU
,
6QSW
,
2WIN
,
1RRK
,
1RTK
GeneCards
P00751
HPA
ENSG00000243649-CFB
Ensembl
ENSG00000243570
,
ENSP00000391902
,
ENSG00000241253
,
ENSP00000389604
,
ENSG00000241534
,
ENSP00000401719
,
ENST00000455591
,
ENST00000426239
,
ENST00000436692
,
ENSP00000388352
,
ENST00000427888
,
ENST00000425368
,
ENST00000399981
,
ENSP00000382862
,
ENSP00000414341
,
ENST00000433503
,
ENSP00000413351
,
ENST00000419411
,
ENSP00000416561
,
ENST00000424727
,
ENSP00000414889
,
ENSP00000411474
,
ENSP00000411515
,
ENST00000419920
,
ENSG00000242335
,
ENST00000417261
,
ENSG00000239754
,
ENSG00000243649
Pharos - Targets
P00751
Orphanet
17195
ZINC - Predictions - Purchasable
CFAB_HUMAN
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
IntAct:EBI-12735745 C3B
0.75
4
UniProt:Q92496-3 CFHR4
0.609
2
UniProt:Q91132 VCO3
0.57
3
UniProt:Q92496-1 CFHR4
0.544
2
UniProt:Q96DX4 RSPRY
0.527
3
UniProt:P61916 NPC2
3
NPC2 [lysosomal lumen]
(R-HSA-8876488)
NPC2 [extracellular region]
(R-HSA-6806224)
NPC2 [azurophil granule lumen]
(R-HSA-6799163)
0.527
2
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