Human CR1 is a potent inhibitor of both the classical and the alternative pathways of complement activation by exhibiting decay-accelerating activity for both C3 and C5 convertases, as well as cofactor activity for factor I-mediated cleavage of C3b and C4b.
Hattori, T, Tamaki, Y, Yamada, N, Oshiumi, H, Mizuno, S, Goitsuka, R, Seya, T, Matsumoto, M, Ohba, S, Katoh, J, Shida, K, Kimura, Y, Inoue, N
Fukui, A, Seya, T, Nishizawa, Y, Inoue, N, Matsumoto, M, Toyoshima, K, Nomura, M
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