Reactome | Histidine is decarboxylated to histamine

Histidine is decarboxylated to histamine

Stable Identifier

R-HSA-977301

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

H(+) + L-histidine => CO2 + histamine

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Histidine is decarboxylated to histamine

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Decarboxylation of L-Histidine happens analogously to other decarboxylations of amino acids. It uses the cofactor pyridoxal phosphate and is catalyzed by histidine decarboxylase (Mamune-Sato et al, 1992).

Literature References

PubMed ID	Title	Journal	Year
1425659	Functional analysis of alternatively spliced transcripts of the human histidine decarboxylase gene and its expression in human tissues and basophilic leukemia cells Shibahara, S, Takishima, T, Maeyama, K, Yamauchi, K, Ohkawara, Y, Mamune-Sato, R, Ohtsu, H, Katayose, D, Watanabe, T, Tanno, Y	Eur J Biochem	1992