Reactome | Histidine is decarboxylated to histamine

Histidine is decarboxylated to histamine

Stable Identifier

R-HSA-977301

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

H(+) + L-histidine => CO2 + histamine

ReviewStatus

5/5

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Histidine is decarboxylated to histamine

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Decarboxylation of L-Histidine happens analogously to other decarboxylations of amino acids. It uses the cofactor pyridoxal phosphate and is catalyzed by histidine decarboxylase (Mamune-Sato et al, 1992).

Literature References

PubMed ID	Title	Journal	Year
1425659	Functional analysis of alternatively spliced transcripts of the human histidine decarboxylase gene and its expression in human tissues and basophilic leukemia cells Mamune-Sato, R, Yamauchi, K, Tanno, Y, Ohkawara, Y, Ohtsu, H, Katayose, D, Maeyama, K, Watanabe, T, Shibahara, S, Takishima, T	Eur J Biochem	1992