Histidine catabolism

Stable Identifier
R-HSA-70921
DOI
10.3180/REACT_1249.2
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Histidine catabolism
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The major pathway of histidine catabolism, annotated here, proceeds in four steps to yield glutamate and, in the process, convert one molecule of tetrahydrofolate to 5-formiminotetrahydrofolate (Morris et al. 1972). Histidine can also be decarboxylated to form histamine. Histidine can also be used to form carnosine (beta-alanyl-L-histidine), an abundant dipeptide in skeletal muscle and brain of most vertebrates.
Literature References
PubMed ID Title Journal Year
5057083 Influence of differential induction of histidine catabolic enzymes on histidine degradation in vivo

Lee, SC, Morris, ML, Harper, AE

J Biol Chem 1972
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Event Information
Go Biological Process
L-histidine catabolic process (0006548)
Orthologous Events
Histidine catabolism (Bos taurus)
Histidine catabolism (Caenorhabditis elegans)
Histidine catabolism (Canis familiaris)
Histidine catabolism (Danio rerio)
Histidine catabolism (Dictyostelium discoideum)
Histidine catabolism (Drosophila melanogaster)
Histidine catabolism (Gallus gallus)
Histidine catabolism (Mus musculus)
Histidine catabolism (Plasmodium falciparum)
Histidine catabolism (Rattus norvegicus)
Histidine catabolism (Saccharomyces cerevisiae)
Histidine catabolism (Schizosaccharomyces pombe)
Histidine catabolism (Sus scrofa)
Histidine catabolism (Xenopus tropicalis)
Authored
D'Eustachio, P  (2003-06-24)
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