Reactome | RBX1:CUL3 dissociates from forming autophagosome

RBX1:CUL3 dissociates from forming autophagosome

Stable Identifier

R-HSA-9766656

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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RBX1:CUL3 dissociates from forming autophagosome

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KEAP1 is a substrate for SQSTM1-mediated autophagy (Zhang et al, 2005; Jain et al, 2010; Fan et al, 2010; Taguchi et al, 2012). Although this has not been described in molecular detail, SQSTM1-dependent targeting of KEAP1 to the autophagosome presumably involves dissociation of KEAP1 and SQSTM1 from RBX1 and CUL3.

Literature References

PubMed ID	Title	Journal	Year
20495340	Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy Zhong, Q, Moughon, D, Chen, D, Fan, W, Zhu, M, Ding, X, Tang, Z, Chen, S	Autophagy	2010
15983046	Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway Sun, Z, Zhang, DD, Hannink, M, Lieberman, MW, Habib, GM, Lo, SC	J Biol Chem	2005
20452972	p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription Larsen, KB, Sjøttem, E, Awuh, JA, Jain, A, Lamark, T, Hayes, JD, Johansen, T, McMahon, M, Øvervatn, A	J Biol Chem	2010
22872865	Keap1 degradation by autophagy for the maintenance of redox homeostasis Motohashi, H, Yamamoto, M, Fujikawa, N, Akaike, T, Komatsu, M, Ishii, T, Unno, M, Taguchi, K	Proc Natl Acad Sci U S A	2012